Background: Pyrrolidine dithiocarbamate (PDTC) is an efficient, reproducible, and biological antioxidant of clinical utility, which may also be preferred for obtaining human dental pulp stem cells (hDPSCs) for the purpose of tissue engineering and regenerative medicine.
Aim And Objectives: The study was conducted to evaluate the effects of PDTC on the propagation and differentiation of hDPSCs.
Materials And Methods: hDPSCs were isolated by explant culture method and characterized for stem cell properties using flow cytometry method. The effects of PDTC-induced odontoblastic differentiation of hDPSC at different concentrations (0.5, 1.0, and 5.0 mM) were determined by staining for mineralization.
Results: Mineralization was more prominent and significantly higher in the induced hDPSCs treated with 1.0 mM concentration of PDTC.
Conclusion: PDTC at 1.0 mM concentration could have a significant pharmacological role in activating and enhancing odontogenic differentiation of dental stem cells and make it an important step in regenerative dentistry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581360 | PMC |
| http://dx.doi.org/10.4103/JCDE.JCDE_356_24 | DOI Listing |
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