Background: Time Activity Data (TAD) describe the timing, duration, and/or frequency of human activities. Given that activity dictates the rate of contact a person has with an environmental agent, activity data can be used to derive rigorous estimates of exposure. TAD has been used to support exposure estimation in a variety of contexts, although there has been no systematic characterization of how TAD has been collected for environmental health applications.
Objectives: We propose a systematic evidence map protocol in pursuit of describing the body of environmental health literature that collects TAD to estimate exposure to chemical, biological, and physical agents. Our work proposes a novel definition for TAD, identifies studies collecting TAD, compiles a list of terms used to describe TAD, and summarizes how this data has been collected to estimate various environmental exposures.
Methods: This protocol details the proposed search strategy, which targets environmental exposure studies that collect information on human activities and when they occur, using Population-Exposure-Method (PEM) criteria. From each study, we will extract data that will be categorized according to a codebook that we develop. In order to refine and improve our methodology iteratively, we will use reflexive journaling to ensure that the data collected are coded and summarized appropriately.
Discussion: We will produce an open-source database and a systematic evidence map depicting the patterns, trends, and gaps existing in the current body of environmental health literature that collects TAD to estimate exposure to environmental agents. Researchers will be able to use this evidence map to assess prominent themes and may reference the database to identify specific studies collecting TAD, which can inform future environmental health research.
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http://dx.doi.org/10.1080/2833373x.2024.2338702 | DOI Listing |
PLoS One
January 2025
FAMERP- Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.
Motivation is of great importance in the teaching-learning process, because motivated students seek out opportunities and show interest and enthusiasm in carrying out their tasks. The objective of this review is to identify and present the information available in the literature on the status quo of motivation among nursing program entrants. This is a qualitative scoping review study, a type of literature review designed to map out and find evidence to address a specific research objective, following the Joanna Briggs Institute methodology.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Background: Recent studies suggest genome-wide-association-studies (GWAS) loci confer their effects on microglia in late-onset Alzheimer's disease (LOAD) brains. Relatively fewer studies have investigated the effects of other genome-wide significant loci (p<5e) using human neurons.
Method: GWAS itself cannot directly identify causal variant-(effector)gene-pairs as GWAS only reports the sentinel variant at a given locus.
Alzheimers Dement
December 2024
Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Background: Disrupted balance between amyloidogenic and non-amyloidogenic pathways leads to cognitive decline in Alzheimer's disease (AD). Evidence suggests vitamin A (VA) supplementation favors the non-amyloidogenic pathway through upregulation of α-secretase. Originally used to map embryonic retinoic acid (RA) signaling, RARE-LacZ mice possess multiple LacZ genes controlled by retinoic acid response elements (RAREs).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio De Janeiro, Rio de Janeiro, Brazil.
Background: Physical exercise has been proposed as an approach to reduce the risk of Alzheimer's disease (AD). Engaging in physical exercise triggers the shedding of the extracellular domain of fibronectin type III domain-containing protein 5 (FNDC5), producing a circulating peptide (irisin) that promotes neuroprotection in AD mouse models. Despite recent evidence indicating that reduced FNDC5/irisin levels in brain and cerebrospinal fluid correlate with amyloid beta pathology, the impact of FNDC5/irisin on tau pathology remains uncertain.
View Article and Find Full Text PDFBackground: microRNAs (miRNAs) are small RNAs involved in regulating gene expression by repressing target protein-coding genes. Hundreds of miRNAs are expressed in human brain, but our understanding of their role in Alzheimer's disease (AD) and cognitive decline is limited.
Method: We performed miRNA differential expression analysis using small RNA sequencing data generated from dorsolateral prefrontal cortex samples from 641 participants of the Religious Orders Study (ROS) and Memory and Aging Project (MAP).
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