Snakebite envenomation is a critical public health issue, especially in tropical regions like India, resulting in significant morbidity and mortality. This review explores the potential of ethnomedicinal herbs as adjunct therapies to conventional antivenoms, addressing challenges such as the high cost, limited availability, and side effects of traditional antivenoms. The study emphasizes regional and species-specific variations in snake venom that complicate antivenom development and highlights the pharmacological potential of certain medicinal plants in mitigating venom effects. These plants offer an affordable, accessible alternative, though their efficacy can vary due to regional venom differences. Additionally, the review discusses the role of bioinformatics in advancing antivenom research, aiming to combine traditional knowledge with modern science to develop effective and accessible snakebite treatments in resource-limited settings.
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http://dx.doi.org/10.1016/j.toxrep.2024.101795 | DOI Listing |
Zhongguo Zhong Yao Za Zhi
December 2024
Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China National Key Laboratory of Classic Formula Modern Chinese Medicine Creation Nanchang 330004, China.
At present, China's traditional Chinese medicine(TCM) industry is developing rapidly with the support of modern science and technology. While promoting economic development and improving national health, it has brought multiple environmental problems. Under the "dual carbon" goals, the ecological fine manufacturing of TCM may become one of the breakthroughs for the TCM industry to practice low-carbon economy.
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January 2025
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Objective: Chronic pain strongly affects the quality of life of patients with liver cancer pain. Safe and effective management of cancer-related pain is a worldwide challenge. Traditional Chinese medicine (TCM) has rich clinical experience in the treatment of cancer pain.
View Article and Find Full Text PDFMater Horiz
January 2025
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Organ-on-a-chip (OoC) is a breakthrough technology in biomedicine. As microphysiological systems constructed , OoCs can simulate the main structures and functions of human organs, thereby providing a powerful tool for drug screening and disease model construction. Furthermore, the coupling of OoCs and sensors has been an innovative discovery in the field of biomedical and electronic engineering in recent years.
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January 2025
Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China. Electronic address:
In recent years, with the deepening understanding of the biological mechanisms underlying tumorigenesis, metabolic reprogramming has emerged as a pivotal process in cancer initiation, progression, and treatment resistance, gradually paving the way for new avenues in precision oncology. Natural herb ingredients, characterized by their multi-target engagement, low toxicity, and wide-ranging biological activities, exhibit unique advantages in anti-cancer therapy. Nonetheless, the clinical application of these components has been constrained by issues such as poor solubility, low bioavailability, and inadequate stability when administered through traditional delivery methods.
View Article and Find Full Text PDFMed Res Rev
January 2025
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Proteins hold pivotal importance since many diseases manifest changes in protein activity. Proteomics techniques provide a comprehensive exploration of protein structure, abundance, and function in biological samples, enabling the holistic characterization of overall changes in organisms. Nowadays, the breadth of emerging methodologies in proteomics is unprecedentedly vast, with constant optimization of technologies in sample processing, data collection, data analysis, and its scope of application is steadily transitioning from the bench to the clinic.
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