While bereavement, particularly the loss of a child, is a well-known risk factor for mental health in the short term, its long-term consequences on depressive mood in old age and across different welfare regimes have been investigated less. This study focused on the combined role of child loss and divorce on depressive symptoms, measured using the EURO-D scale in Central, Nordic, Southern, and Eastern European countries. We used data from the European SHARE project, covering 22,959 participants aged 50+ over a 16-year period. Using OLS regressions, we found that, compared to no child loss and no divorce, the association between depressive symptoms and child loss was significant ( = 0.22, 95% C.I. = [0.13, 0.30]), among both women and men. The absolute increase was even stronger when the mutual effect of child loss and divorce was considered ( = 0.34, 95% C.I. = [0.18, 0.48]). Employing Generalized Estimating Equations, we found that depressive symptoms related to divorce did not increase over time, regardless of past bereavement. Compared with people in the Nordic countries, those living in Southern Europe experienced more depressive symptoms related to child loss and no divorce, but fewer depressive symptoms related to the combined effect of child loss and divorce. In sum, our findings indicate that bereavement due to child loss may lead to more depressive symptoms among both women and men in old age, especially in combination with divorce. In the latter case, we posit that participants living in Southern European countries may be protected by higher levels of social support through family ties or informal social networks.
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http://dx.doi.org/10.1016/j.ssmph.2024.101721 | DOI Listing |
Afr J Reprod Health
December 2024
Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
This was an original article, and the objective of this study was to investigate the effects of bipolar transurethral plasma kinetic prostatectomy (TUPKP) on urodynamics and sexual function in benign prostatic hyperplasia (BPH) patients. One hundred and four BPH patients were divided into a control group and an intervention group. The control group received transurethral resection of prostate, while the intervention group received TUKEP.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Discipline of Pharmacology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.
: Ongoing challenges in epilepsy therapy warrant research on alternative treatments that offer improved efficacy and reduced side effects. Designed to enhance mitochondrial targeting and increase bioavailability, mitocurcumin (MitoCur) was evaluated for the first time as an antiepileptic agent, with curcumin (Cur) and sodium valproate (VPA), a standard antiepileptic drug, included for comparison. This study investigated the effects on seizure onset, severity, and progression in a zebrafish model of pentylenetetrazole (PTZ)-induced seizures and measured the concentrations of the compounds in brain tissue.
View Article and Find Full Text PDFMolecules
December 2024
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.
Mild hypophosphatasia (HPP) can be difficult to distinguish from other bone disorders in the absence of typical symptoms such as the premature loss of primary teeth. Therefore, this study aimed to analyze the crystallinity of hydroxyapatite (HAp) and the three-dimensional structure of collagen in HPP teeth at the molecular level and to search for new biomarkers of HPP. Raman spectroscopy was used to investigate the molecular structure, composition, and mechanical properties of primary teeth from healthy individuals and patients with HPP.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Biomedical and Biotechnological Sciences, Section of Clinical Biochemistry and Medical Genetics, University of Catania, via Santa Sofia, 95123 Catania, Italy.
This study describes two siblings from consanguineous parents who exhibit intellectual disability, microcephaly, photosensitivity, bilateral sensorineural hearing loss, numerous freckles, and other clinical features that suggest a potential disruption of the nucleotide excision repair (NER) pathway. Whole exome sequencing (WES) identified a novel homozygous missense variant in the gene, which was predicted to be pathogenic. However, a subsequent peculiar audiometric finding prompted further investigation, revealing a homozygous deletion in the gene linked to neurosensorial hearing loss.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Pathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70121 Bari, Italy.
Chromosomal abnormalities (CAs) are changes in the number or structure of chromosomes, manifested as alterations in the total number of chromosomes or as structural abnormalities involving the loss, duplication, or rearrangement of chromosomal segments. CAs can be inherited or can occur spontaneously, leading to congenital malformations and genetic diseases. CAs associated with cardiovascular diseases cause structural or functional alterations of the heart, affecting the cardiac chambers, valves, coronary arteries, aorta, and cardiac conduction, thus increasing the likelihood of arrhythmias, cardiac arrest, and sudden cardiac death (SCD).
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