Background: Time-resolved 3D cine phase-contrast cardiovascular magnetic resonance (4D flow CMR) enables the characterization of blood flow using basic and advanced hemodynamic parameters. However, different confounders, e.g., different field strength, scanner configurations, or sequences, might impact 4D flow CMR measurements. This study aimed to analyze the inter-site reproducibility of 4D flow CMR to determine the influence of said confounders.
Methods: A cohort of 19 healthy traveling volunteers underwent 4D flow CMR at four different sites (Sites I-III: 3 T scanner; Site IV: 1.5 T scanner; all Siemens Healthineers, Erlangen, Germany). Two protocols of one 4D flow CMR research sequence were performed, one acquiring velocity vector fields in the thoracic aorta only and one in the entire heart and thoracic aorta combined. Basic and advanced hemodynamic parameters, i.e., forward flow volume (FFV), peak and mean velocities (Vp and Vm), and wall shear stress (3D WSS), at nine different planes across the thoracic aorta (P1-P2 ascending aorta, P3-P5 aortic arch, P6-P9 descending aorta) were analyzed. Based on a second scan at Site I, mean values and tolerance ranges (TOL) were generated for inter-site comparison. Equivalency was assumed when confidence intervals of Sites II-IV lay within such TOL. Additionally, inter- and intra-observer analysis as well as a comparison between the two protocols was performed, using an intraclass correlation coefficient (ICC).
Results: Inter-site comparability showed equivalency in P1 and P2 for FFV, Vp, and Vm at all sites. Non-equivalency was present in various planes of P3-P9 and in P2 for 3D WSS in one protocol. In total, Site IV showed the most disagreements. Protocol comparison yielded excellent (>0.9) ICC in every plane for FFV, good (0.75-0.9) to excellent ICC for Vm and 3D WSS, good to excellent ICC in eight planes for Vp, and moderate (0.5-0.75) ICC in one plane for Vp. Inter- and intra-observer analysis showed excellent agreement for every parameter.
Conclusions: Basic and advanced hemodynamic parameters revealed equivalency at different sites and field strength in the ascending aorta, a clinically important region of interest, under a highly controlled environment.
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http://dx.doi.org/10.3389/fcvm.2024.1456814 | DOI Listing |
Interdiscip Cardiovasc Thorac Surg
December 2024
Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Objectives: The common surgical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is septal myectomy. This involves resection of a segment of the myocardial septum and can be performed with and without concomitant anterior mitral valve leaflet extension (AMVLE). While both approaches have satisfying clinical outcomes, there is a lack of data regarding the added value of concomitant AMVLE.
View Article and Find Full Text PDFCardiol Discov
December 2024
Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
The assessment of cardiac function using echocardiography has gained a strong foothold in clinical practice. Cardiac magnetic resonance (CMR) imaging harbors distinct advantages over echocardiography, as it is not affected by limitations of acoustic windows and operator dependence. CMR is also designed to non-invasively assess cardiac morphology, ventricular geometry, myocardial wall motion, and intra-cardiac flow quantification without the use of ionizing radiation.
View Article and Find Full Text PDFJ Cardiovasc Magn Reson
December 2024
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China; Clinical Research Center for Medical Imaging in Hunan Province, Changsha, China. Electronic address:
Background: Cardiac involvement in light chain (AL) amyloidosis is the main determinant of prognosis. Amyloid can be deposited in the extracellular space and cause an increase in extracellular volume (ECV). At the same time, amyloid can also be deposited in the wall of small vessels and cause microvascular dysfunction.
View Article and Find Full Text PDFEcol Evol
December 2024
Molecular Breeding and Biodiversity Group, Department of Genetics Stellenbosch University Stellenbosch South Africa.
Globally, hammerhead sharks have experienced severe declines owing to continued overexploitation and anthropogenic change. The smooth hammerhead shark remains understudied compared to other members of the family Sphyrnidae. Despite its vulnerable status, a comprehensive understanding of its genetic landscape remains lacking in many regions worldwide.
View Article and Find Full Text PDFBMC Med Imaging
December 2024
National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Background: Current mainstream cardiovascular magnetic resonance-feature tracking (CMR-FT) methods, including optical flow and pairwise registration, often suffer from the drift effect caused by accumulative tracking errors. Here, we developed a CMR-FT method based on deformable groupwise registration with a locally low-rank (LLR) dissimilarity metric to improve myocardial tracking and strain estimation accuracy.
Methods: The proposed method, Groupwise-LLR, performs feature tracking by iteratively updating the entire displacement field across all cardiac phases to minimize the sum of the patchwise signal ranks of the deformed movie.
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