Objective: There is a need for improved diagnostic tools in Amyotrophic Lateral Sclerosis (ALS). Our objective was to assess muscle ultrasound as a diagnostic tool in patients with ALS and determine a simplified screening protocol to aid implementation in clinical practice.
Methods: Ultrasound of bulbar and limb muscles was prospectively performed on all patients referred to a single centre with suspected ALS. Clinical measures of disease severity and upper motor neuron impairment were also recorded. Receiver operating characteristic (ROC) curves were calculated to assess the diagnostic utility of muscle ultrasound.
Results: 94 patients initially suspected of ALS were recruited to this observational cohort study. Forty-four were subsequently diagnosed as ALS and 50 as disease mimics. ALS patients demonstrated a higher frequency and more generalised distribution of fasciculations compared to mimics. A simplified 5 muscle screening protocol exhibited an AUC of 0.94 (95 %CI 0.89-0.99) in discriminating ALS from mimics. The presence of ≥ 3 fasciculating muscles detected using this screening protocol was 89 % sensitive and 88 % specific for the diagnosis of ALS.
Conclusions: Muscle ultrasound, screening as few as 5 muscles, has diagnostic utility in ALS.
Significance: Muscle ultrasound enhances clinical diagnosis in ALS.
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http://dx.doi.org/10.1016/j.clinph.2024.11.008 | DOI Listing |
Rev Bras Ortop (Sao Paulo)
December 2024
Departamento de Ortopedia e Anestesiologia, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
This study presents a retrospective study of persistent median artery associated with carpal tunnel syndrome (CTS). A retrospective study of the persistent median artery and CTS. Exclusion criteria were patients who did not present persistent median artery, those who were diabetic, or had rheumatoid diseases, and those who decided not to do the surgery.
View Article and Find Full Text PDFClin Anat
December 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatomical structures underneath bunny lines and their relationships with adjacent muscular structures.
View Article and Find Full Text PDFBMC Cardiovasc Disord
December 2024
Department of Radiology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Background: The aim of this study was to evaluate the prognostic impact of computed tomography (CT)-based body composition parameters in metabolically unhealthy normal-weight patients (MUHNW) with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).
Methods: This prospective cohort study involved adults with normal weight scheduled for TAVR. Patients were divided into two groups: metabolically healthy normal-weight (MHNW) and MUHNW.
Clin Biomech (Bristol)
December 2024
Department of Rehabilitation Sciences, Musculoskeletal Rehabilitation Research Group, Katholieke Universiteit Leuven (KU Leuven), Bruges, Belgium; Universitaire Ziekenhuizen KU Leuven (UZ Leuven), Campus Pellenberg, Clinical Motion Analysis Laboratorium (CMAL), Lubbeek, Belgium; Haute Ecole Leonard De Vinci, Secteur Santé, Département de Podologie, Brussels, Belgium.
Background: Specific foot exercises and the use of minimalist shoes during running or daily life were suggested to strengthen the intrinsic foot muscles and to modify locomotion biomechanics. We aimed to review the effectiveness of these interventions to modify foot muscle sizes, foot strength, and biomechanical outcomes.
Method: PubMed, Embase, Cochrane Library and SportDiscus databases were searched (last update: 12 March 2024).
Clin Physiol Funct Imaging
January 2025
Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
The present study examined the relationships between trunk tissue distribution, metabolic risk factors, and physical performance in young Japanese individuals using cross-sectional and longitudinal analyses. Thirty-six healthy Japanese men (n = 20, body mass index [BMI]: 20.8 ± 2.
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