Introduction: Microscopic polyangiitis (MPA) with interstitial lung disease (ILD) has a significant impact on morbidity and mortality. This study evaluated the clinical characteristics, treatment responses, and prognostic factors of patients with ANCA-associated vasculitis with ILD (AAV-ILD) and pulmonary limited vasculitis (PLV).
Patients And Methods: A retrospective chart review of ILD patients positive for MPO-ANCA was conducted from 2008 to 2021. Patients were classified into AAV-ILD or PLV groups. Data included laboratory test results, pulmonary function tests, and high-resolution computed tomography (HRCT) images. Statistical analyses were used to assess group differences and survival outcomes.
Results: Of 114 patients, 80 were diagnosed with PLV and 34 with AAV-ILD. The AAV-ILD group had higher corticosteroid treatment rates, higher serum creatinine levels, and better survival than the PLV group. The PLV group had higher KL-6 levels, lower %VC and % FVC in pulmonary function tests. Survival in the PLV group was significantly worse than that in the AAV-ILD group, and survival of patients with an alternative diagnosis on HRCT was better than that of patients with a UIP pattern. Cox regression analysis identified a diagnosis of MPA and HRCT classification as significant prognostic factors.
Conclusions: Patients with AAV-ILD had a better prognosis than those with PLV. HRCT patterns, particularly an alternative diagnosis on HRCT, were associated significantly with a favourable prognosis. The efficacy of corticosteroid treatment in PLV patients was limited. These findings highlight the importance of early and accurate diagnosis, as well as careful consideration of treatment strategies, for patients with in MPO-ANCA-positive ILD.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.resinv.2024.11.006 | DOI Listing |
Respir Investig
January 2025
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Cogn Neurodyn
October 2024
Rehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, No.42, Wenhuaxi Road Lixia District, Jinan, 250012 Shandong China.
Spinal cord injury (SCI), which is the injury of the spinal cord site resulting in motor dysfunction, has prompted the use of motor imagery (MI)-based brain computer interface (BCI) systems for motor function reconstruction. However, analyzing electroencephalogram signals and brain function mechanisms for SCI patients is challenging. This is due to their low signal-to-noise ratio and high variability.
View Article and Find Full Text PDFMed Pharm Rep
October 2024
Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Aim: This study investigates the demographic distribution, antibiotic resistance profiles, and molecular characteristics of infections.
Methods: The study was carried out in 141 patients, 60.4% male, in patients from Chania and Heraklion, Crete.
Front Aging Neurosci
October 2024
Digital Health Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Background: This study utilized recent advancements in electroencephalography (EEG) technology that enable the measurement of prefrontal event-related potentials (ERPs) to facilitate the early detection of mild cognitive impairment (MCI). We investigated two-channel prefrontal ERP signals obtained from a large cohort of elderly participants and compare among cognitively normal (CN), subjective cognitive decline (SCD), amnestic MCI (aMCI), and nonamnestic MCI (naMCI) groups.
Methods: Signal processing and ERP component analyses, specifically adapted for two-channel prefrontal ERP signals evoked by the auditory oddball task, were performed on a total of 1,754 elderly participants.
J Affect Disord
January 2025
School of Psychology, University of East London, London, UK; Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK. Electronic address:
Aim: To investigate oscillatory networks in bipolar depression, effects of a home-based tDCS treatment protocol, and potential predictors of clinical response.
Methods: 20 participants (14 women) with bipolar disorder, mean age 50.75 ± 10.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!