AI Article Synopsis
- A study reports a new type of negative myoclonus observed in three patients with acute post-anoxic brain injury (PABI).
- The researchers analyzed EEG and muscle recordings, revealing a pattern of whole body tonic posturing accompanied by brief periods of muscle relaxation in two out of the three patients.
- The findings suggest that this phenomenon can be identified using sEMG and may involve cortical or reticular brain regions, contributing to our understanding of brain recovery after oxygen deprivation.
Article Abstract
Objective: To report a novel phenotype of negative myoclonus in acute post-anoxic brain injury (PABI).
Methods: We performed a retrospective analysis of 18-channel video-EEG and surface-EMG (sEMG) recordings of three patients with PABI. sEMG electrodes were placed on the neck, bulbar and arm muscles.
Results: All three patients had whole body tonic posturing with intermittent brief relaxation. In patients #1 and #2, a generalized EEG burst-suppression was present. Repetitive silent periods (SPs) were noted in the sEMG channels, time-locked to EEG bursts. The bursts preceded the SPs by 135 ms and 124 ms, respectively. The average SP duration was 910 ms and 852 ms in patients #1 and 2, respectively. Patient #3 had a generalized background suppression pattern and average SP duration of 272.5 ms. The SP recruitment pattern in patient #1 was rostro-caudal whereas patient #3 had a variable recruitment pattern.
Conclusion: Acute post-anoxic negative myoclonus can be detected in comatose patients with sEMG electrodes. The muscle SPs produce intermittent relaxation of the tonic posturing. The putative generator can be cortical or reticular, similar to Lance-Adams syndrome.
Significance: We describe a novel phenotype of negative myoclonus in acute PABI. We also describe the EEG and sEMG characteristics and the localization of the putative generator.
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| http://dx.doi.org/10.1016/j.clinph.2024.11.010 | DOI Listing |
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Article Synopsis
- A study reports a new type of negative myoclonus observed in three patients with acute post-anoxic brain injury (PABI).
- The researchers analyzed EEG and muscle recordings, revealing a pattern of whole body tonic posturing accompanied by brief periods of muscle relaxation in two out of the three patients.
- The findings suggest that this phenomenon can be identified using sEMG and may involve cortical or reticular brain regions, contributing to our understanding of brain recovery after oxygen deprivation.
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