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Efficacy and safety of immunotherapy for head and neck squamous cell carcinoma: a meta-analysis of randomized clinical trials.
Front Oncol
January 2025
Department of Oral and Maxillofacial Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of cancer worldwide and immune checkpoint inhibitors have shown favorable therapeutic effects in recurrent or metastatic or locally advanced head and neck squamous cell carcinoma (R/M/LA HNSCC). However, the effects of immunotherapy in HNSCC are still inconsistent because of complicating factors. This meta-analysis tries to provide a more precise assessment of the efficacy and safety of this integrated approach in HNSCC.
View Article and Find Full Text PDFPiloting a battery to evaluate parasympathetic reactivity and externalizing behaviours during early childhood in autism spectrum disorder.
Infant Child Dev
April 2024
Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States.
Background: Respiratory Sinus Arrhythmia Reactivity (RSA-R) correlates both positively and negatively with externalizing behavior in autistic individuals. These inconsistencies may result from task-based differences. This pilot study measured RSA-R in 4-to 6-year-olds, across two time-points, using four validated tasks with matched baseline and challenge periods.
View Article and Find Full Text PDFStorage stability evaluation of chicken seasoning by accelerating oil oxidation under different storage conditions.
Food Res Int
February 2025
College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China; Wilmar (Shanghai) Biotechnology Research and Development Center Co., Ltd., Pudong New District, Shanghai 200137, China. Electronic address:
The effects of temperature, humidity, and UV irradiation on the accelerated oil oxidation of chicken seasoning (CS) were investigated, aiming to establish a method for evaluating its storage stability. Key oxidation indicators, such as peroxide value (POV), fatty acid profile, and volatile aldehydes, were measured to assess the degree of oil oxidation. The results indicated that oil oxidation of CS is not significantly accelerated by temperatures of 50-80 °C due to the inhibitory effects of the Maillard reaction.
View Article and Find Full Text PDFMicroorganism-mediated production of anthocyanins: Current progress and future prospects.
Food Res Int
February 2025
College of Food Science, Shenyang Agricultural of University, No. 120, Dongling Road, Shenhe District, Shenyang 100866, China. Electronic address:
Anthocyanins are a type of water-soluble pigments widely distributed in colorful plants, which have been extensively used in food and cosmetics industry. The current production of anthocyanins heavily depends on extraction from plant materials, which leads to low purity and inconsistency among batches. Compared with conventional extraction, microorganism-mediated production of anthocyanins has advantages such as a short production cycle, high purity, low waste production, low energy requirements, and consistency between different batches.
View Article and Find Full Text PDFMesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations.
Stem Cell Res Ther
January 2025
Grupo de Investigación en Terapia Celular y Medicina Regenerativa, Instituto de Investigación Biomédica de A Coruña (INIBIC), Fundación Pública Gallega de Investigación Biomédica INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, 15006, Spain.
Background: Articular cartilage injuries can lead to pain, stiffness, and reduced mobility, and may eventually progress to osteoarthritis (OA). Despite substantial research efforts, effective therapies capable of regenerating cartilage are still lacking. Mesenchymal stromal cells (MSCs) are known for their differentiation and immunomodulatory capabilities, yet challenges such as limited survival post-injection and inconsistent therapeutic outcomes hinder their clinical application.
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