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PSRC1 could serve as a prognostic biomarker for patients with kidney renal clear cell carcinoma.
Asian J Surg
November 2024
Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen Longhua District Key Laboratory for Diagnosis and Treatment of Chronic Kidney Disease, Shenzhen, Guangdong, 518110, China. Electronic address:
Article Synopsis
- This study investigates the relationship between mitosis-related genes and clinical outcomes in colon cancer, aiming to create a predictive model to better understand tumor progression and immune responses.
- Using data from 453 colon cancer patients, the researchers identified 17 key mitosis-related genes and developed a model that demonstrates strong predictive abilities for patient survival across different datasets.
- The model also integrates factors like immune cell functions and provides tools (like nomograms) for predicting survival rates at 3, 5, and 7 years, showcasing its potential for improving colon cancer prognosis.
A Bruton tyrosine kinase inhibitor-resistance gene signature predicts prognosis and identifies TRIP13 as a potential therapeutic target in diffuse large B-cell lymphoma.
Sci Rep
September 2024
Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Article Synopsis
- * Researchers identified a 10-gene signature (including CARD16, TRIP13, and others) linked to BTKi resistance, allowing for early identification of high-risk DLBCL patients and improving prognosis predictions through a nomogram.
- * The key gene TRIP13 was overexpressed in both DLBCL and BTKi-resistant cell lines; reducing its levels decreased cell proliferation and enhanced the effects of BTKi, suggesting it could be a target for treatment in resistant
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors.
Comput Struct Biotechnol J
May 2022
Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760, České Budějovice 370 05, Czech Republic.
Tick-borne encephalitis virus (TBEV), the most medically relevant tick-transmitted flavivirus in Eurasia, targets the host central nervous system and frequently causes severe encephalitis. The severity of TBEV-induced neuropathogenesis is highly cell-type specific and the exact mechanism responsible for such differences has not been fully described yet. Thus, we performed a comprehensive analysis of alterations in host poly-(A)/miRNA/lncRNA expression upon TBEV infection in human primary neurons (high cytopathic effect) and astrocytes (low cytopathic effect).
View Article and Find Full Text PDFDevelopment and Validation of a Pyroptosis-Related Signature for Predicting Prognosis in Hepatocellular Carcinoma.
Front Genet
January 2022
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hepatocellular carcinoma (HCC) has emerged as a primary health problem and threat to global mortality, especially in China. Since pyroptosis as a new field for HCC prognosis is not well studied, it is important to open a specific prognostic model. In this study, consensus clustering method for 42 pyroptosis-related genes to classify 374 HCC patients in the TCGA database.
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