AI Article Synopsis
- - Dopamine (DA) is an important neurotransmitter in the brain that influences perception, cognition, and hormone secretion, making its monitoring crucial for diagnosing neurological disorders.
- - The study developed a method that generates fluorescence specifically for DA detection by linking it to an HClO oxidation reaction, allowing for DA visualization in cellular models.
- - This research is pioneering in using an organic fluorescent molecular probe to detect DA within living cells, enhancing the understanding of DA's role in various health conditions.
Article Abstract
Background: Dopamine (DA) is a significant neurotransmitter and catecholamine molecule in the mammalian brain. It plays a crucial role in perception, cognition, central nervous system regulation, and hormone secretion. The detection of DA levels in living systems is a vital aspect of the research and early diagnosis of neurological disorders.
Results: In this study, we achieved an effective fluorescence generation specific to DA under physiological pH conditions by coupling the DA detection reaction to the HClO oxidation reaction. This method has been used for the detection of DA in cells, as well as for the visualization of DA levels in cellular models of inflammation and depression.
Significance: This is the first time that utilizes an organic fluorescent molecular probe to detect DA in living cells.
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| http://dx.doi.org/10.1016/j.aca.2024.343358 | DOI Listing |
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