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The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke.
Neurochem Res
January 2025
Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in ischemic stroke. We employed weighted gene co-expression network analysis (WGCNA) to construct two co-expression networks for mRNAs with circRNAs and lncRNAs, respectively, to investigate their association with ischemic stroke. We compared the overlap of mRNAs and biological pathways in the stroke-associated modules of the two networks.
View Article and Find Full Text PDF[microRNAs: regulators of metamorphosis in insects].
Biol Aujourdhui
January 2025
Sorbonne Université, Université Paris-Est Créteil, INRAE, CNRS, IRD, Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), 4 place Jussieu, F-75005 Paris, France.
In the animal kingdom, metamorphosis is a well-known developmental transition within various taxa (Cnidarians, Echinoderms, Molluscs, Arthropods, Vertebrates, etc.), which is characterized by the switching from a larval stage to an adult form through the induction of morpho-anatomical, physiological, behavioral, and/or ecological changes. Over the last decades, numerous studies have focused on the hormonal control of cellular processes underlying metamorphosis.
View Article and Find Full Text PDFEpigenetic Modifications in HBV-Related Hepatocellular Carcinoma.
J Viral Hepat
February 2025
Medical School, Kunming University of Science and Technology, Kunming, People's Republic of China.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Hepatitis B virus (HBV) is the main pathogen for HCC development. HBV covalently closed circular DNA (cccDNA) forms extra-host chromatin-like minichromosomes in the nucleus of hepatocytes with host histones, non-histones, HBV X protein (HBx) and HBV core protein (HBc).
View Article and Find Full Text PDFHOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.
Biomark Med
January 2025
Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.
Methods: We searched the literature for studies on HOTAIR expression in GBM patients.
Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies.
Alzheimers Dement
January 2025
Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Introduction: Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear.
Methods: Baseline and longitudinal associations of nutritional status with NPSs were analyzed in 374 patients on the AD continuum and 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, and differentially gene expression were evaluated in standard and malnourished diet-fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice.
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