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Extracellular vesicles of ADSCs inhibit ischemic stroke-induced pyroptosis through Gbp3 regulation: A role for the NLRP3/GSDMD signaling pathway.
Int Immunopharmacol
December 2024
Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:
Background: Mounting data indicates that extracellular vesicles (EVs) have the potential to improve the injury after a stroke. Pyroptosis is a recently identified kind of programmed cell death that initiates an inflammatory reaction. We aimed to ascertain the therapeutic implications and possible molecular processes of EVs obtained from adipose-derived stem cells (ADSCs) in inhibiting pyroptosis in ischemic stroke.
View Article and Find Full Text PDFBletilla striata polysaccharide-mediated trained immunity drives the hematopoietic progenitors' expansion and myelopoiesis.
Int Immunopharmacol
December 2024
Jiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascular Remodeling Diseases, Jiangxi University of Chinese Medicine, Nanchang 330006, China; National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herb Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China; Department of Cardiovascular Sciences and Centre for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:
Trained immunity represents a functional state of the innate immune response, characterized by enduring epigenetic reprogramming of innate immune cells. This phenomenon facilitates a sustained and advantageous reaction of myeloid cells to subsequent challenges. Bletilla striata polysaccharide (BSP) is the primary active component of Bletilla striata, mainly consisting of mannose and glucose in its chemical structure.
View Article and Find Full Text PDFA pathway-based genetic score for inflammation: An indicator of vulnerability to phthalate-induced adverse neurodevelopment outcomes.
Int J Hyg Environ Health
December 2024
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia; Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, 3052, Australia.
Introduction: Phthalates, chemical additives used to enhance plastic products' flexibility, are easily released into the environment, and can harm the brain development through various mechanisms including inflammation. Genetic variation influencing an individual's susceptibility to inflammation may play a role in the effects of phthalate exposure on neurodevelopment however there is no summary measure developed for genetic susceptibility to inflammation.
Methods: We developed a genetic pathway function score for inflammation (gPFS), based on the transcriptional activity of the inflammatory response pathway in the brain and other tissues.
Physiological and transcriptomic analysis of purple flowering stalks (Brassica campestris var. purpurea) under cadmium stress and exogenous glutathione application.
Plant Physiol Biochem
December 2024
College of Horticulture, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address:
Glutathione (GSH) has a beneficial effect on the response of plants to cadmium (Cd) stress. The physiological and molecular processes by which glutathione influences Cd tolerance in purple flowering stalks (a Brassica vegetable) remain unclear. The aim of this study was to investigate the role of exogenous GSH in alleviating Cd toxicity in purple flowering stalks.
View Article and Find Full Text PDFProgrammable Wrinkled MXene-Based Soft Actuators with Moisture- and Light-Responsive Deformation and Water-Surface Locomotion Capabilities.
ACS Appl Mater Interfaces
December 2024
School of Material Science and Engineering, Shanghai University of Engineering Science, Shanghai 201620, P.R. China.
Soft actuators are limited by single-mode driving technology, which poses challenges in dealing with complex and multidimensional movements. In this study, a multiresponsive soft actuator was fabricated by integrating a microwrinkling structure into an MXene-based film, enabling programmable motions. To achieve this, we introduced -hexane into the film preparation process and utilized its rapid volatilization to accelerate the shrinkage difference between the film and the substrate.
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