AI Article Synopsis
- Lichen planus (LP) is a chronic inflammatory disease affecting the skin and mucous membranes, with a low overall prevalence of about 0.15% among U.S. adults, higher in females compared to males.
- Among over half a million patients studied, 1,098 had LP, with many (53%) receiving no treatment after a year; topical corticosteroids were the most common initial therapy.
- The findings highlight the need for further research on treatment options since patients on systemic immunosuppressants were more likely to continue or switch treatments after a year.
Article Abstract
Background: Lichen planus (LP) is a chronic mucocutaneous inflammatory disease with significant morbidity but data on epidemiology and therapeutics for LP is limited.
Objective: To describe overall prevalence of LP and dermatologist-prescribed LP treatments in US adults.
Methods: Using the Explorys database, we analyzed prevalence of overall LP and dermatologists' utilization of medications of interest.
Results: Among 566,851 eligible patients in the prevalence analysis, there were 1098 LP cases with a median age of 66 years. Overall crude prevalence of LP was 0.19% (95% CI 0.18-0.21) with higher prevalence in females (prevalence ratio vs males 1.77, 95% CI 1.53-2.05). Standardized overall prevalence was 0.15%. Most LP patients diagnosed by dermatologists remained untreated after 1 year (n = 1061, 53%); the most common initial treatment was topical corticosteroids (38%). Treatment continuation after 1 year and switching were most common after initial use of systemic immunosuppressants (28% and 46%, respectively).
Limitations: The lack of a precise diagnosis code for nonoral LP allows for the potential of misclassification; disease severity cannot be established.
Conclusions And Relevance: Standardized prevalence of overall LP was 0.15%. For patients requiring systemic immunosuppressive medications, treatment continuation and switching were more common, suggesting that further research into medication selection for LP may be clinically beneficial.
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| http://dx.doi.org/10.1016/j.jaad.2024.09.081 | DOI Listing |
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