Carbohydrate (CHO) gels are a staple among endurance athletes. When ingested during competition, CHO gels can improve endurance performance by acting as an external energy substrate, sparing endogenous glycogen, mitigating the risk of hypoglycemia, and engaging the central nervous system via receptors in the mouth and gastrointestinal tract. However, published studies and a growing number of anecdotal reports have raised concerns about possible energy and macronutrient deficiencies in several products. We therefore performed a content analysis on CHO gels from Gu Energy, Honey Stinger, Hüma, Maurten, Näak, Precision Fuel, Science in Sport, and Spring Energy. On average, products contained significantly less energy than stated on the labels (n = 8, p = .047, large effect) but with no discrepancy in CHO content (n = 8, p = .219, medium effect). Bland-Altman analyses revealed a systematic bias toward less energy and CHO in measured samples relative to the label-derived nutritional information. Moreover, the Spring Energy product fell outside the 95% limits of agreement for both energy and CHO, containing ∼71% less energy (53 vs. 180 kcal) and ∼72% less CHO (12.5 vs. 45 g) than stated on the label. A follow-up analysis revealed similar discrepancies in several Spring Energy products from multiple lots. These findings have performance, clinical, and legal implications.
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http://dx.doi.org/10.1123/ijsnem.2024-0174 | DOI Listing |
Carbohydr Polym
March 2025
College of Chemistry and Environment, Southwest Minzu University, Chengdu, Sichuan 610225, China; Key Laboratory of Fundamental Chemistry of the State Ethnic Commission, College of Chemistry and Environment, Southwest Minzu University, Chengdu, Sichuan 610225, China. Electronic address:
Cholesterol (CHO) is an essential lipid in cell membranes and a precursor for vital living substances. Abnormal CHO levels can cause cardiovascular diseases. Therefore, simple and accurate monitoring of CHO levels is crucial for early diagnosis and effective management of cardiovascular diseases.
View Article and Find Full Text PDFNutrients
December 2024
Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Palle Juul-Jensens Boulevard 165, 8200 Aarhus, Denmark.
Background: This study aimed to compare the effects of a carbohydrate (CHO) hydrogel with (ALG-CP) or without (ALG-C) branched-chain amino acids, and a CHO-only non-hydrogel (CON), on cycling performance. The hydrogels, encapsulated in an alginate matrix, are designed to control CHO release, potentially optimising absorption, increasing substrate utilisation, and reducing gastrointestinal distress as well as carious lesions.
Methods: In a randomised, double-blinded, crossover trial, 10 trained male cyclists/triathletes completed three experimental days separated by ~6 days.
Gels
December 2024
College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Inje-ro, Gimhae 50834, Republic of Korea.
The objective of this work was to develop a supersaturated gel formulation (SGF) loaded with the maximum atorvastatin calcium trihydrate (ATR) dose. The maximum dose strength of ATR needs to be reduced through improving solubility and dissolution rate to mitigate side effects due to the necessity of taking high doses. ATR has highly pH-dependent solubility at 37 °C, leading to poor solubility (<10 μg/mL) in stomach acid (pH 1.
View Article and Find Full Text PDFGels
November 2024
Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1, Kuzuhahanazono-cho, Hirakata-shi 573-1121, Osaka, Japan.
Bone tissue engineering is a technique that simulates the bone tissue microenvironment by utilizing cells, tissue scaffolds, and growth factors. The collagen hydrogel is a three-dimensional network bionic material that has properties and structures comparable to those of the extracellular matrix (ECM), making it an ideal scaffold and drug delivery system for tissue engineering. The clinical applications of this material are restricted due to its low mechanical strength.
View Article and Find Full Text PDFMol Pharm
January 2025
Industrial Pharmacy, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Glioblastoma multiforme is the most frequently diagnosed primary malignant brain tumor. Despite multimodal therapy with surgical resection, radiation therapy, and chemotherapy, recurrence of the tumor is almost always guaranteed due to the infiltrative nature of the disease. Moreover, the blood brain barrier imparts an additional layer of complexity by impeding the delivery of therapeutic agents to the tumor, hence limiting the efficacy of systemically delivered drugs.
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