AI Article Synopsis
- - The complement system is essential for both innate and adaptive immunity, helping to eliminate pathogens and damaged cells like cancer cells.
- - It is highly regulated and works closely with cell-mediated immunity, affecting how immune responses are carried out.
- - In the tumor microenvironment, the complement system has both immune and non-immune roles that can enhance immune evasion and support tumor growth, sometimes regardless of complement activation.
Article Abstract
The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system performs both immune and nonimmune functions in tumor and immune cells through pathways that depend on or are independent of complement activation, thereby promoting immune evasion and tumor progression.
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| http://dx.doi.org/10.1016/j.smim.2024.101912 | DOI Listing |
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