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Exploring heterogeneity of perimenopause with application of multivariable analysis approaches.
BMC Womens Health
December 2024
Gynecology Clinic, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510632, China.
Article Synopsis
- This study aimed to understand the varying symptoms of perimenopause by using advanced statistical methods to create a comprehensive assessment framework that combines multiple scales related to insomnia, anxiety, and depression.
- A clinical study in Guangzhou enrolled 336 perimenopausal patients, and a framework was developed to identify six factors affecting their experience, such as sleep disturbance and fatigue, validated through psychometric analysis.
- The findings suggested four distinct profiles of perimenopause symptoms, highlighting the complex and varied nature of the condition across different individuals.
Effects of different postures on the hemodynamics and cardiovascular autonomic control responses to exercise in postural orthostatic tachycardia syndrome.
Eur J Appl Physiol
November 2024
Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
Article Synopsis
- The study examined how body positions (supine vs. upright) affect heart and blood pressure responses during exercise in patients with postural orthostatic tachycardia syndrome (POTS) compared to healthy controls.
- Results showed that POTS patients experienced increased heart rates and sympathetic activity while upright, along with decreased baroreflex sensitivity, indicating cardiovascular issues in this position.
- Conversely, during supine exercise, POTS patients had similar cardiovascular responses to healthy controls, suggesting that supine exercise may be a better option for their rehabilitation.*
Basics of vasomotor symptoms.
Menopause
December 2024
From the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; and Department of Psychology, University of Pittsburgh, Pittsburgh, PA.
The gamma rhythm as a guardian of brain health.
Elife
November 2024
Transylvanian Institute of Neuroscience, Department of Experimental and Theoretical Neuroscience, Cluj-Napoca, Romania.
Gamma oscillations in brain activity (30-150 Hz) have been studied for over 80 years. Although in the past three decades significant progress has been made to try to understand their functional role, a definitive answer regarding their causal implication in perception, cognition, and behavior still lies ahead of us. Here, we first review the basic neural mechanisms that give rise to gamma oscillations and then focus on two main pillars of exploration.
View Article and Find Full Text PDFOvercoming challenges in conducting early phase breast cancer prevention trials: Bazedoxifene and conjugated estrogens vs waitlist control.
Contemp Clin Trials
November 2024
University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Background: The combination of bazedoxifene 20 mg (BZA) and conjugated estrogens 0.45 mg (CE) marketed as Duavee® is approved for vasomotor symptom relief and osteoporosis prevention. Our pilot study suggested it had potential breast cancer risk reduction, and we proposed a multisite Phase IIB primary prevention trial assessing change in breast imaging and tissue risk biomarkers.
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