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ACBP orchestrates the metabolic phenotype in Cushing's syndrome.
Nat Metab
December 2024
University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
HIF-1-dependent regulation of lifespan in by the acyl-CoA-binding protein MAA-1.
Aging (Albany NY)
July 2017
Institut de Génomique Fonctionnelle de Lyon, Centre National de la Recherche Scientifique, Université de Lyon 1, Ecole Normale Supérieure, Lyon, France.
In yeast, the broadly conserved acyl-CoA-binding protein (ACBP) is a negative regulator of stress resistance and longevity. Here, we have turned to the nematode as a model organism in which to determine whether ACBPs play similar roles in multicellular organisms. We systematically inactivated each of the seven ACBP paralogs and found that one of them, (which encodes membrane-associated ACBP 1), is indeed involved in the regulation of longevity.
View Article and Find Full Text PDFPregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes.
J Biol Chem
July 2010
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0368, USA.
Acyl-CoA-binding protein (ACBP) functions both intracellularly as part of fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine peptides. Two of these peptides, ODN and TTN, bind to the GABA(A) receptor and modulate its sensitivity to gamma-aminobutyric acid (GABA). We have found that depolarization of mouse primary astrocytes induces the rapid release and processing of ACBP to the active peptides.
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