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Edible bird's nest: N- and O-glycan analysis and synergistic anti-avian influenza virus activity with neuraminidase inhibitors. | LitMetric

AI Article Synopsis

  • * Edible bird's nest (EBN), which is swiftlet saliva consumed for health benefits, shows anti-avian viral properties, particularly by inhibiting the receptor-binding hemagglutinin (HA) activity after pancreatin treatment.
  • * EBN, rich in specific glycan structures, effectively enhances the action of antiviral drugs oseltamivir and zanamivir, suggesting its potential as a food-derived solution to combat avian viruses and reduce the risk of pandemics.

Article Abstract

Zoonotic avian influenza viruses have continued to infect people on occasion. During treatment, antiviral resistant viruses have occasionally emerged, highlighting the need for a novel strategy for treating human illness. After pancreatin treatment, edible bird's nest (EBN), swiftlet saliva consumed for health purposes, possesses anti-avian viral activity by inhibiting receptor-binding hemagglutinin (HA) activity. Glycan analysis revealed an abundance of α2,3Neu5Ac decoy receptors in pancreatin-treated EBN. Fucosylated tri-α2,3Neu5Ac tri-antennary N-glycans (N-35) and di-α2,3Neu5Ac core 2 O-glycans (O-15) are predominant, accounting for 53.46% and 44.66% of total N- and O-glycan amounts, respectively. Isobologram analysis revealed that the treated EBN had a strong synergistic effect with either oseltamivir carboxylate or zanamivir, a competitive inhibitor of receptor-destroying neuraminidases (NAs), against the avian H5N1 virus. Taken together, EBN has the potential to be developed as a food-derived avian viral trap to prevent and decrease avian virus infection as well as in combination with a viral releasing-NA inhibitor to increase therapeutic potency, reduce toxicity, delay resistance development, and potentially prevent pandemic onset.

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Source
http://dx.doi.org/10.1016/j.antiviral.2024.106040DOI Listing

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