Microbial pathogens such as bacteria and fungi form biofilms, which represent substantial hurdles in treating human illness owing to their adaptive resistance mechanism to conventional antibiotics. Biofilm may cause persistent infection in a variety of bodily areas, including wounds, oral cavity, and vaginal canal. Using invasive devices such as implants and catheters contributes significantly to developing healthcare-associated infections because they offer an ideal surface for biofilm formation. Marine organisms produce a variety of polysaccharides, which have recently attracted worldwide attention due to their biochemical features, various applications, and advantageous properties such as bioactivity, biodegradability, and biocompatibility. Because of their antimicrobial and antibiofilm features, several polysaccharides such as chitosan, fucoidan, carrageenan, alginate, and hyaluronic acid have been used to treat infected wounds as well as ophthalmic, oral, and vaginal infections. In addition, marine polysaccharides are currently employed as coatings on medical devices and implant materials, alone or in combination with other bioactive substances or nanomaterials, to protect the materials' undertones from microbial contamination. This review discussed the recent advancements in marine polysaccharides and their derivatives as a therapeutic potential against biofilm-associated diseases. The potential obstacles in the scalability of their production, clinical translation, and/or regulatory hurdles have also been discussed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.ijbiomac.2024.137786 | DOI Listing |
mSystems
December 2024
School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
The genus () is most often associated with human clinical samples and livestock. However, are also prevalent in the hindgut of the marine herbivorous fish (Silver Drummer), and analysis of their carbohydrate-active enzyme (CAZyme) encoding gene repertoires suggests degrade macroalgal biomass to support fish nutrition. To further explore host-associated traits unique to -derived , we compared 445 high-quality genomes of available in public databases (e.
View Article and Find Full Text PDFGlycobiology
December 2024
Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Fucosylated chondroitin sulfate (FCS) is a unique polysaccharide, first described nearly four decades ago, and found exclusively in sea cucumbers. It is a component of the extracellular matrix, possibly associated with peculiar properties of the invertebrate tissue. The carbohydrate features a chondroitin sulfate core with branches of sulfated α-Fuc linked to position 3 of the β-GlcA.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Shandong 264209, PR China. Electronic address:
Bacterial exopolysaccharides (EPS) are secondary metabolites of microorganisms which play important roles in adhesion, protection, biofilm formation, and as a source of nutrition. Compared with polysaccharides obtained from animal and plant species, bacterial polysaccharides have significant advantages in terms of production cost and large-scale production due to their abundant metabolic pathways and efficient polysaccharide production capacity. Most extracellular polysaccharides are water-soluble, and some are insoluble, such as bacterial cellulose.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Yunnan Province Key Lab of Wood Adhesives and Glued Products, International Joint Research Center for Biomass Materials, School of Materials and Chemical Engineering, Southwest Forestry University, Kunming 650224, China; Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains, Ministry of Education, Southwest Forestry University, Kunming 650224, China. Electronic address:
The wood industry's dependence on traditional petrochemical adhesives, which pose environmental and health risks, has spurred research into sustainable alternatives. Sustainable bio-based polysaccharide materials show promise due to their inherent adhesive properties, despite challenges related to mechanical weaknesses and water resistance. Inspired by the hardening mechanisms of nacre and arthropod cuticles, we have developed a novel biomimetic flame-retardant HPA/OCTS/VMT NSs-NH adhesive.
View Article and Find Full Text PDFPhytochemistry
December 2024
College of Marine Sciences and Biotechnology, Guangxi Key Laboratory of Polysaccharide Materials and Modification, Guangxi Minzu University, Nanning 530008, China. Electronic address:
Nine previously undescribed azulenoid-type sesquiterpenoids, including four common (1-4), four 5/6-cleaved (5-8), and one rearranged (9), were isolated from the edible-medicinal fungi Irpex lacteus. The structures of the compounds were established by combining spectroscopic methods, including integrated NMR, MS, and UV, as well as quantum C NMR and ECD calculations. All compounds exhibited a meaningful reduction in triglycerides activity.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!