The overall aim of the present study was to understand how dancers' perception and parents' own perceptions of parents' responsiveness and competence support were associated with dancers' self-perceptions and thriving. In total, 64 dancers and 91 parents for a total of 52 matching dyads participated in the study. Dancers were aged 7-24 years, trained on average 4.17 times/weeks, and were involved in Irish dancing for an average of 9.71 years. Participants completed self-reported questionnaires assessing their perceived responsiveness, competence support, self-perceptions, and thriving. Main analyses consisted of mediations performed with structural equation modeling. Results demonstrate that dancers' perceptions of their parents' responsiveness and competence support are associated with their self-perceptions and thriving. Responsiveness and competence support of their second parent was more strongly associated with thriving than responsiveness and competence support of the main parent. Parents' own perceptions of competence support were positively associated with dancers' thriving.
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http://dx.doi.org/10.1123/jsep.2024-0180 | DOI Listing |
JACS Au
December 2024
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China.
Macrocyclization is a compelling strategy for conventional drug design for improving biological activity, target specificity, and metabolic stability, but it was rarely applied to the design of PROTACs possibly due to the mechanism and structural complexity. Herein, we report the rational design of the first series of "Head-to-Tail" macrocyclic PROTACs. The resulting molecule exhibited pronounced Brd4 protein degradation with low nM DC values while almost totally dismissing the "hook effect", which is a general character and common concern of a PROTAC, in multiple cancer cell lines.
View Article and Find Full Text PDFJACS Au
December 2024
Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269-3060, United States.
Red-light absorbing photoredox catalysts offer potential advantages for large-scale reactions, expanding the range of usable substrates and facilitating bio-orthogonal applications. While many red-light absorbing/emitting fluorophores have been developed recently, functional red-light absorbing photoredox catalysts are scarce. Many photoredox catalysts rely on long-lived triplet excited states (triplets), which can efficiently engage in single electron transfer (SET) reactions with substrates.
View Article and Find Full Text PDFPerspect Med Educ
December 2024
School of Health Professions Education (SHE), Faculty of Health, Medicine and Life sciences, Maastricht University, Maastricht, The Netherlands.
Introduction: Undergraduate healthcare students on placement abroad can experience challenges that affect their wellbeing, personal and professional development. These challenges may result in students taking a more peripheral role in workplace activities, which negatively impacts learning. We studied .
View Article and Find Full Text PDFInt J Ment Health Addict
December 2024
Department of Psychology, University of Waterloo, Waterloo, ON, Canada.
This study examined differences in quit attempts, 1-month quit success, and vaping status at follow-up among a cohort of 3709 daily smokers with and without depression, anxiety, and regular alcohol use who participated in both the 2018 and 2020 International Tobacco Control Four Country Smoking and Vaping (ITC 4CV) Surveys. At baseline, a survey with validated screening tools was used to classify respondents as having no, or one or more of the following: 1) depression, 2) anxiety, and 3) regular alcohol use. Multivariable adjusted regression analyses were used to examine whether baseline (2018) self-report conditions were associated with quit attempts; quit success; and vaping status by follow-up (2020).
View Article and Find Full Text PDFJAMIA Open
February 2025
Georgia Tech Research Institute, Atlanta, GA 30308, United States.
Objective: The resurgence of syphilis in the United States presents a significant public health challenge. Much of the information needed for syphilis surveillance resides in electronic health records (EHRs). In this manuscript, we describe a surveillance platform for automating the extraction of EHR data, known as SmartChart Suite, and the results from a pilot.
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