Decoding retrons: Breakthroughs in RT-DNA production and genome editing.

Cell Chem Biol

Key Laboratory of Biomass Chemical Engineering of Ministry of Education & State Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310000, China. Electronic address:

Published: November 2024

AI Article Synopsis

  • Retrons are important for defense against viruses (phages) and for engineering bacterial genomes.
  • Despite their significance, only a limited number of retrons have been thoroughly studied until now.
  • The August issue of Nature Biotechnology features a study by Khan et al., which presents hundreds of retrons that have been experimentally researched, advancing our understanding of bacterial immunity and genome engineering.

Article Abstract

Retrons are notable for their anti-phage defense functions and genome engineering applications. However, only a few retrons have been well characterized. In the August issue of Nature Biotechnology, Khan et al. present hundreds of experimentally studied retrons, which are critical for bacterial immunity research and retron-based genome engineering technologies.

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http://dx.doi.org/10.1016/j.chembiol.2024.10.011DOI Listing

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