In children with recurrent secretory otitis media (SOM) a mechanical malfunction of the Tuba Eustachii (by adenoids, myogenous palatotubal insufficiency, persistent cartilaginous collapse of the tube) should be taken into consideration as well as immunological factors of the lymphatic structures of the pharynx which may influence the tubotympanal mucosa. The pharyngeal tonsil and the tubotympanal mucosa are part of the immune system of the mucosa which itself has a regulating immunological function and importance as do the central and peripheral lymphatic organs. The lymphatic ring of Waldeyer regulates the reactivity of the tubotympanal mucosa in a similar way as the plaques of Peyer do control and influence immunologically the mucosa of the guts. The importance of persisting infections in the pharyngeal tonsil (by adenovirus, pneumococcus, H. influenzae) as well as the influence of IgG-mediated immune complex reaction for the perpetuation of inflammatory processes of the middle ear mucosa are discussed. The question to which extent the hyperergic immune reaction is pathogenetically involved in the secretory otitis media is thoroughly discussed. Compared to the other immune mechanisms the hyperergic immune reaction is of minor importance and may be considered as a predisposing factor.
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[Evolution of the tubotympanal mucociliary system activity evaluated with scintigraphy, after ventilation tube insertion in adults with chronic otitis media with effusion].
Acta Otorrinolaringol Esp
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Introduction And Goals: Tubotympanal mucociliary function is damaged in patients with otitis media with effusion. Our objective was to study its situation and recovery after timopanostomy tube insertion.
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Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae.
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View Article and Find Full Text PDF[Surfactants of the airways. Critical review and personal research].
Acta Otorhinolaryngol Ital
February 1997
Clinica Otorinolaringoiatrica, Università di Pavia.
The literature proving the presence of a surface tension lowering substance (STLS) on the lining layer of mammalian Eustachian tube (ET) is critically reviewed. A further review of the chemical studies on tubal washings based on chromatographic analysis methods (TLC and HPLC) is performed, and is concluded that ET epithelium is coated by a mixture of phospholipids, similar but not identical to the pulmonary surfactant and with similar but less powerful surface activity. In both cases, and with minor differences between the different mammalian species, phosphatidylcholine (PC), and in particular its disaturated fraction, dipalmitoilphosphatidylcholine (DPPC), is the predominating and the most active compound.
View Article and Find Full Text PDFIn children with recurrent secretory otitis media (SOM) a mechanical malfunction of the Tuba Eustachii (by adenoids, myogenous palatotubal insufficiency, persistent cartilaginous collapse of the tube) should be taken into consideration as well as immunological factors of the lymphatic structures of the pharynx which may influence the tubotympanal mucosa. The pharyngeal tonsil and the tubotympanal mucosa are part of the immune system of the mucosa which itself has a regulating immunological function and importance as do the central and peripheral lymphatic organs. The lymphatic ring of Waldeyer regulates the reactivity of the tubotympanal mucosa in a similar way as the plaques of Peyer do control and influence immunologically the mucosa of the guts.
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