Systemic immune-inflammation index and 2-year all-cause mortality in elderly patients with hip fracture.

Arch Gerontol Geriatr

Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China, 100853; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China, 100853. Electronic address:

Published: February 2025

AI Article Synopsis

  • The study aimed to evaluate how the systemic immune-inflammation index (SII) relates to the risk of dying within two years in older patients who suffered hip fractures.
  • A cohort of hip fracture patients aged 65 and older was analyzed, with SII calculated from blood tests, and patients were divided into three groups based on their SII scores.
  • Findings showed that higher SII levels correlated with increased mortality risk, indicating that SII could help identify older patients who are at a higher risk of death following hip fracture surgery.

Article Abstract

Purpose: To assess the association between systemic immune-inflammation index (SII) and 2-year all-cause mortality in elderly patients with hip fractures.

Methods: We performed a cohort study of hip fracture patients aged 65 years or older who received hip fracture surgery at a tertiary hospital from January 2005 to March 2022. The SII was calculated as: SII = (neutrophil count * platelet count) / lymphocyte count, based on the latest blood test before discharge. Patients were categorized into 3 groups according to SII tertiles: low SII group (≤770.92 × 10/L), medium SII group (770.92 × 10/L -1293.03 × 10/L), and high SII group (>1293.03 × 10/L). The primary outcome was 2-year all-cause mortality. We evaluated the association between SII and 2-year all-cause mortality using the multivariate Cox regression model.

Results: Among 2766 patients, 296 patients died during the 2-year follow-up period. The incidence of 2-year all-cause mortality per 1000 persons was 90.0 (95 % CI: 73.2-110.2) in the low SII group, 86.8 (95 % CI: 70.3-106.7) in the medium SII group, and 144.3 (95 % CI: 123.1-168.5) in the high SII group. Compared with patients in the low SII group, the hazard ratio for 2-year all-cause mortality was 0.97 (95 % CI: 0.69-1.37) in the medium SII group and 1.47 (95 % CI: 1.07-2.01) in the high SII group (P for trend, 0.010).

Conclusion: SII is significantly associated with 2-year all-cause mortality in elderly patients with hip fracture. SII may be used to identify patients at high risk of mortality after hip fracture surgery.

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Source
http://dx.doi.org/10.1016/j.archger.2024.105695DOI Listing

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