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Pathology discovered in the "first patient" can be the silent teacher of self-directed learning.
Clin Anat
December 2024
Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Pathology found during cadaveric dissection has been used to model integrative teaching methods for medical students at several institutions. Recent evidence has shown that pathology found during dissection can be used in the design of self-directed learning (SDL) activities with standards that are difficult to meet. This study presents a novel method for providing formative feedback, one of the most challenging aspects for LCME accreditation of SDL activities.
View Article and Find Full Text PDFContextual modulation emerges by integrating feedforward and feedback processing in mouse visual cortex.
Cell Rep
December 2024
Center for Theoretical Neuroscience and Mortimer B Zuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY 10027, USA; Department of Neuroscience, Swartz Program in Theoretical Neuroscience, Kavli Institute for Brain Science, College of Physicians and Surgeons and Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY 10027, USA.
Sensory systems use context to infer meaning. Accordingly, context profoundly influences neural responses to sensory stimuli. However, a cohesive understanding of the circuit mechanisms governing contextual effects across different stimulus conditions is still lacking.
View Article and Find Full Text PDFRegulation of DNA Topology in Archaea: State of the Art and Perspectives.
Mol Microbiol
December 2024
CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, France.
DNA topology is a direct consequence of the double helical nature of DNA and is defined by how the two complementary DNA strands are intertwined. Virtually every reaction involving DNA is influenced by DNA topology or has topological effects. It is therefore of fundamental importance to understand how this phenomenon is controlled in living cells.
View Article and Find Full Text PDFNon-pharmacological treatment strategies for anthropometric, physical capacity and physiological indicators among sarcopenic obesity patients: a systematic review of rigorous randomized controlled trials.
Age Ageing
November 2024
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Article Synopsis
- The study aimed to explore how non-drug treatments affect sarcopenic obesity (SO) through a meta-analysis of randomized controlled trials (RCTs).
- Results indicated that exercise and nutrition can improve various physical health metrics, such as body fat percentage (PBF) and grip strength, but individual interventions showed limited effectiveness.
- The combination of exercise and nutritional interventions proved to be the most effective approach for improving outcomes related to SO, highlighting the potential role of physical therapy as well.
An update on multiple breath washout in children with cystic fibrosis.
Expert Rev Respir Med
December 2024
Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Introduction: Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane regulator (CFTR) gene, leading to progressive lung disease and systemic complications. Lung disease remains the primary cause of morbidity and mortality, making early detection of lung function decline crucial. The Lung Clearance Index (LCI), derived from the multiple breath washout (MBW) test, has emerged as a sensitive measure for identifying early airway disease.
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