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Associations between health-related quality of life, infertility-related psychological well-being, and relationship quality in individuals with endometriosis: A cross-sectional study.
BMC Womens Health
December 2024
Department of Developmental and Educational Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria.
Background: Endometriosis is the most frequent gynecological diseases and accompanied by both physical and psychological symptoms. An increasing number of studies suggested acknowledging endometriosis as a systematic disease due to the multifactorial effects throughout the body. The chronic disease significantly impacts daily life, including romantic relationships.
View Article and Find Full Text PDFEmpowering informal caregivers and nurses to take a person-centred view: adaptation and clinical utility of the Integrated Palliative Outcome Scale (IPOS-Dem) for use in acute and community care settings.
BMC Geriatr
December 2024
Department of Health Sciences, Institute of Nursing, ZHAW Zurich University of Applied Sciences, Katharina-Sulzer Platz 9, CH-8400, Winterthur, Switzerland.
Background: Dementia is a progressive and terminal illness. Symptoms are present for people with dementia across all stages, leading to poor quality of life and considerable carer burden. In acute and community care services, no holistic, person-centred outcome tools are available for nurses and informal caregivers to measure symptoms and needs from the person`s with dementia point of view.
View Article and Find Full Text PDFDigital divide as a determinant of health in the U.S. older adults: prevalence, trends, and risk factors.
BMC Geriatr
December 2024
School of Nursing, University of Michigan, Ann Arbor, USA.
Background: The rapid development of digital technologies has fundamentally changed the care for older adults. However, not all older adults have equal opportunities to access and use the technologies, more importantly, be able to benefit from the technologies. We aimed to explore (1) the prevalence and the trend in the prevalence of digital divide in older adults, including digital access gap, digital use gap (specifically, using digital technologies for health commutation [e-communication gap]), and self-efficacy in information seeking gap (cognitive gap); (2) sociodemographic factors related to three perspectives of digital divide; and (3) the association between digital divide and self-rated health (exploratory).
View Article and Find Full Text PDFHEK-omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing.
Biotechnol Adv
December 2024
BioCurie, Inc., Wilmington, DE, United States. Electronic address:
Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, robust, scalable, industrialized production is required to meet demand and provide affordable patient access, which has not yet materialized. Closing the chasm between demand and supply requires innovation in biomanufacturing to achieve the essential step change in rAAV product yield and quality.
View Article and Find Full Text PDFSatXplor-a comprehensive pipeline for satellite DNA analyses in complex genome assemblies.
Brief Bioinform
November 2024
Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
Satellite DNAs (satDNAs) are tandemly repeated sequences that make up a significant portion of almost all eukaryotic genomes. Although satDNAs have been shown to play an important role in genome organization and evolution, they are relatively poorly analyzed, even in model organisms. One of the main reasons for the current lack of in-depth studies on satDNAs is their underrepresentation in genome assemblies.
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