A 52-year-old man presented with a one-year history of episodic unilateral facial numbness, jaw weakness, ptosis, and hoarseness. Brain imaging was unremarkable and an 11.5cm right lower thoracic mass was discovered on chest x-ray, which was further evaluated by CT and MRI radiology. The lesion was biopsied, and histopathological examination revealed a thymoma. A diagnosis of ectopic thymoma with paraneoplastic myasthenia gravis was supported by positive anti-acetylcholine receptor and anti-titin serum antibodies. Paraneoplastic syndromes are rarely reported in association with ectopic thymoma, making this case unusual. We discuss the nuances of diagnosis, classification, and staging of this rare case, as well as the patient's subsequent management by cardiothoracic surgery and neurology specialists.
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http://dx.doi.org/10.7759/cureus.72146 | DOI Listing |
Cureus
October 2024
Histopathology, Royal College of Surgeons in Ireland, Dublin, IRL.
A 52-year-old man presented with a one-year history of episodic unilateral facial numbness, jaw weakness, ptosis, and hoarseness. Brain imaging was unremarkable and an 11.5cm right lower thoracic mass was discovered on chest x-ray, which was further evaluated by CT and MRI radiology.
View Article and Find Full Text PDFCureus
September 2024
Pathology, NMC Royal Hospital, Abu Dhabi, ARE.
Intrathyroidal thymoma is a rare tumor that can be challenging to diagnose due to its unusual location and resemblance to more common thyroid conditions. We present the case of a 58-year-old woman with an incidentally discovered thyroid nodule during evaluation for an upper respiratory infection. Ultrasonography revealed an exophytic nodule in the left thyroid lobe, categorized as TR 3.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
October 2024
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Raipur, CG India.
Thymus is a paired organ which develops during the sixth week of fetal life, attains maximum size by three years and involutes in adult life. Anatomically it is situated in superior mediastinum. Thymus can be present at ectopic sites like neck, skull base, middle ear, submandibular gland and tonsil.
View Article and Find Full Text PDFCell Rep
September 2024
Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Osaka, Japan.
Asian J Surg
October 2024
Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, 116027, Dalian, China. Electronic address:
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