AI Article Synopsis
- - The study examined the chemical diversity of the SWUF15-40 fungus grown in a yeast-malt extract medium, shifting from the previous PDB medium using the OSMACs strategy, which resulted in discovering numerous bioactive compounds.
- - Detailed analysis using IR, NMR, MS, and XRD techniques led to the identification of two new isopimarane derivatives, three guaiane derivatives, and four known compounds.
- - A cyclic pentapeptide from the fungus showed promising anti-cancer activity against several cell lines and inhibited nitric oxide production, indicating that adjusting growth conditions can enhance the discovery of bioactive compounds in fungi.
Article Abstract
The chemical diversity from SWUF15-40 fungus, cultivated in yeast-malt extract medium was studied. The choice of medium was inspired by the OSMACs strategy, which had previously been cultivated in PDB medium. This resulted in an array of bioactive compounds being discovered. The IR, NMR, MS, and XRD data, together with the calculated C NMR chemical shifts and ECD spectra data were thoroughly analysed, which led to the determination of two new isopimarane ( and ), and three guaiane (-) derivatives, together with four known compounds (-). Cyclic pentapeptide () showed inhibitory activity against cancer cells (HeLa, HT-29, PC-3, and A549) proliferation and nitric oxide (NO) production in LPS-stimulated RAW264.7 cells with IC values in the ranges of 11.38 - 17.87 µM, and 58.88 µg/mL, respectively. The results demonstrated that manipulating growth conditions can increase the possibility of discovering many more bioactive compounds in fungi.
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| http://dx.doi.org/10.1080/14786419.2024.2432611 | DOI Listing |
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