AI Article Synopsis
- The text explores the complex landscape of RNA modifications, known as the epitranscriptome, highlighting over 170 identified modifications that significantly influence RNA metabolism and various biological processes.
- It specifically examines key RNA modifications and their effects on mRNA, tRNA, and rRNA during mammalian reproduction and embryonic development, detailing how these modifications impact RNA processing and function.
- The review emphasizes the linkage between RNA modification dysfunctions and diseases, underlining their importance in critical developmental events, while also suggesting areas for future research to better understand these processes.
Article Abstract
The intricate world of RNA modifications, collectively termed the epitranscriptome, covers over 170 identified modifications and impacts RNA metabolism and, consequently, almost all biological processes. In this review, we focus on the regulatory roles and biological functions of a panel of dominant RNA modifications (including m A, m C, Ψ, ac C, m A, and m G) on three RNA types-mRNA, tRNA, and rRNA-in mammalian development, particularly in the context of reproduction as well as embryonic development. We discuss in detail how those modifications, along with their regulatory proteins, affect RNA processing, structure, localization, stability, and translation efficiency. We also highlight the associations among dysfunctions in RNA modification-related proteins, abnormal modification deposition and various diseases, emphasizing the roles of RNA modifications in critical developmental processes such as stem cell self-renewal and cell fate transition. Elucidating the molecular mechanisms by which RNA modifications influence diverse developmental processes holds promise for developing innovative strategies to manage developmental disorders. Finally, we outline several unexplored areas in the field of RNA modification that warrant further investigation.
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| http://dx.doi.org/10.3724/abbs.2024201 | DOI Listing |
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