The carrier-envelope phase (CEP) of a laser pulse plays a crucial role in laser-matter interactions. The inherent shot-to-shot instability of the CEP necessitates single-shot detection, which is not only vital for stabilizing the CEP but also for observing ultrafast phenomena that conventional averaging techniques cannot resolve. In this study, we demonstrate a novel approach utilizing strong-field ionization in ambient air for single-shot CEP measurement. Our method is applicable without the need for an imaging device, providing a practical and precise solution for high-repetition-rate CEP measurement.
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http://dx.doi.org/10.1364/OE.530546 | DOI Listing |
Se Pu
January 2025
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Ambient mass spectrometry imaging (MSI) enables hundreds of analytes in tissue sections to be directly mapped at atmospheric pressure with minimal sample preparation. This field is currently experiencing rapid growth, with numerous reported ambient ionization techniques resulting in a "hundred flowers bloom" situation. Nanospray desorption electrospray ionization (nano-DESI), developed by the Laskin group in 2010, is a widely used liquid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012.
View Article and Find Full Text PDFSe Pu
January 2025
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Lipids are indispensable components of living organisms and play pivotal roles in cell-membrane fluidity, energy provision, and neurotransmitter transmission and transport. Lipids can act as potential biomarkers of diseases given their abilities to indicate cell-growth status. For example, the lipid-metabolism processes of cancer cells are distinct from those of normal cells owing to their rapid proliferation and adaptation to ever-changing biological environments.
View Article and Find Full Text PDFAnal Chem
December 2024
Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
In ambient mass spectrometry, the performance in direct in situ analysis applications has been hindered by the lack of efficient ion-transferring technique between the atmosphere pressure ionization source and the mass analyzer. Building upon the hybrid concept of a stack ring ion guide and multipole ion guide, this study proposes the concept of a reconfigurable twisted dipole ion guide (TDIG) that enables flexible ion transfer between atmosphere and vacuum. Initially, theoretical and numerical studies were conducted to understand the basic ion confining principle of the twisted dipole ion guide, revealing its unique merits in long-distance flexible ion transmission.
View Article and Find Full Text PDFACS Meas Sci Au
December 2024
Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7K 0C2.
Ambient mass spectrometry (MS) technologies have been applied to spatial metabolomic profiling of various samples in an attempt to both increase analysis speed and reduce the length of sample preparation. Recent studies, however, have focused on improving the spatial resolution of ambient approaches. Finer resolution requires greater analysis times and commensurate computing power for more sophisticated data analysis algorithms and larger data sets.
View Article and Find Full Text PDFJ Med Biochem
September 2024
University of Verona, Section of Clinical Biochemistry and School of Medicine, Verona, Italy.
Background: Minimizing air aspiration by carefully filling blood gas syringes is crucial to prevent air contamination from causing undesirable variations in gasses and other molecules. While some previous studies investigated this aspect, these are now outdated and only analyzed a limited number of blood gas parameters. Thus, we investigated the effects air contamination in the syringe using a modern blood gas analyzer.
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