Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/d41586-024-03818-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and snake venoms.
Toxicon X
December 2024
Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Snakebites profoundly impact the rural population of tropical nations, leading to significant socio-economic repercussions. Polyvalent antivenom (PAV) therapy faces several limitations, including intra-specific variations and poor efficacy against some major toxins and low molecular mass, poorly immunogenic toxins, which contribute to increased mortality and morbidity rates. Innovative strategies for developing novel antivenoms are continuously explored to address these challenges.
View Article and Find Full Text PDFNeutralizing Nanobodies against Venoms from Species Captured in North Africa.
Toxins (Basel)
September 2024
Laboratory of Venoms and Theranostic Applications (LR20IPT01), Place Pasteur, BP704, Pasteur Institute of Tunis, Université Tunis el Manar, Tunis 1002, Tunisia.
Article Synopsis
- Snakebite envenoming (SBE) is a major public health problem in tropical areas, especially Africa, where it causes a high number of fatalities and serious health issues due to ineffective antivenom treatments.
- This study focuses on developing nanobodies as a new type of treatment against cobra venoms, investigating toxic venom fractions and their interaction with acetylcholine receptors.
- The research identified two particularly deadly venom fractions, F5 and F6, and demonstrated that combining specific nanobodies could neutralize these venoms effectively in mice, revealing the complex nature of cobra venom's lethal effects.
V-ToCs (Venom Toxin Clustering): A tool for the investigation of sequence and structure similarities in snake venom toxins.
Toxicon
November 2024
Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address:
Recently, there has been a major push toward the development of next-generation treatments against snakebite envenoming. However, unlike current antivenoms that rely on animal-derived polyclonal antibodies, most of these novel approaches are reliant on an in-depth understanding of the over 2000 known snake venom toxins. Indeed, by identifying similarities (i.
View Article and Find Full Text PDFProteomic diversity of Russell's viper venom: exploring PLA2 isoforms, pharmacological effects, and inhibitory approaches.
Arch Toxicol
November 2024
Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Snakebite envenomation is a serious health concern in tropical regions, resulting in high mortality. The World Health Organization (WHO) has declared it a neglected tropical disease and is working on strategies to reduce mortality. Russell's viper (Daboia russelii) is one of the most abundant venomous snakes found across Southeast Asia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!