Helicobacter pylori infection is a major risk factor for gastric adenocarcinomas. In the case of the intestinal subtype, chronic gastritis and intestinal metaplasia are well-known sequential steps in carcinogenesis. H. pylori has high genetic diversity that can modulate virulence and pathogenicity in the human host as a cag Pathogenicity Island (cagPAI). However, bacterial gene combinations do not always explain the clinical presentation of the disease, indicating that other factors associated with H. pylori may play a role in the development of gastric disease. In this context, we characterized the microbial composition of patients with chronic gastritis (inactive and active), intestinal metaplasia, and gastric cancer as well as their potential association with H. pylori. To this end, 16 S rRNA metagenomic analysis was performed on gastric mucosa samples from patients with different types of lesions and normal gastric tissues. Our main finding was that H. pylori virulence status can contribute to significant differences in the constitution of the gastric microbiota between the sequential steps of the carcinogenesis cascade. Differential microbiota was observed in inactive and active gastritis dependent of the H. pylori presence and status (p = 0.000575). Pseudomonades, the most abundant order in the gastritis, was associated the presence of non-virulent H. pylori in the active gastritis. Notably, there are indicator genera according to H. pylori status that are poorly associated with diseases and provide additional evidence that the microbiota, in addition to H. pylori, is relevant to gastric carcinogenesis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582621 | PMC |
http://dx.doi.org/10.1038/s41598-024-80394-2 | DOI Listing |
IJID Reg
March 2025
Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Objectives: To delineate and understand the genetic variations among strains from Trinidad and Tobago associated with gastric diseases.
Methods: One hundred (n = 100) patients who routinely presented with clinical features suggestive of peptic disease were enrolled in the study and underwent gastroscopy procedures. Biopsy specimens were analyzed using serological and molecular methods.
Korean J Gastroenterol
December 2024
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in Korea has not been reported largely because, it is a relatively rare disease. Gastric MALT lymphoma is clinically important because of the high prevalence of () in Korea. The endoscopic findings of gastric MALT lymphoma are diverse, and it is often challenging to differentiate from gastric adenocarcinoma.
View Article and Find Full Text PDFCurr Rev Clin Exp Pharmacol
December 2024
School of Pharmaceutical Sciences, Siksha O Anusandhan deemed to be University, Bhubaneswar, India.
The estimated worldwide number of individuals diagnosed with Parkinson's disease (PD) might exceed 10 million by 2040. However, the underlying evidence for PD is unclear. Recent research in Parkinson's disease has focused on exploring the gut-brain axis.
View Article and Find Full Text PDFWorld J Gastroenterol
December 2024
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Background: () infection exhibits a familial clustering phenomenon.
Aim: To investigate the prevalence of infection, identify associated factors, and analyze patterns of transmission within families residing in the community.
Methods: From July 2021 to September 2021, a total of 191 families (519 people) in two randomly chosen community health service centers in the Chengguan District of Lanzhou in Gansu Province, were recruited to fill out questionnaires and tested for infection.
World J Gastroenterol
December 2024
Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Background: () is a prevalent pathogen associated with various diseases. Cholelithiasis is also a common condition. infection has been identified in the biliary system, suggesting its potential involvement in biliary diseases.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!