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Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins. | LitMetric
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Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins.

A A Semendyaev M A Darenskaya D A Stupin S I Kolesnikov N V Semenova D V Tukhieva L I Kolesnikova

Bull Exp Biol Med

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Published: November 2024

AI Article Synopsis

  • The study analyzed the enzymatic activity of several dehydrogenases in lymphocytes from 183 women with pelvic varicose veins (PVV) and a control group of 30 women.
  • Results showed that women with stage II PVV had increased activity in certain enzymes like NAD-GDH and lactate dehydrogenase, while showing decreased activity in NAD-ICDH.
  • In stage III PVV, lower levels of succinate dehydrogenase and NAD-MDH were observed, alongside increased levels of other enzymes, highlighting changes in enzyme activity as the disease progresses and suggesting potential for targeted treatment options.

Article Abstract

The activities of NAD- and NADP-dependent isocitrate dehydrogenases (NAD-ICDH and NADP-ICDH), NAD- and NADP-dependent glutamate dehydrogenases (NAD-GDH and NADP-GDH), and NAD- and NADP-dependent malate dehydrogenases (NAD-MDH and NADP-MDH) in ovarian veins lymphocytes in 183 women of reproductive age with pelvic varicose veins (PVV) and 30 women in the control group were determined. The indicators of intracellular enzymatic activity showed multidirectional changes with increasing severity of the disease. Compared to the control group, women with stage II of PVV had higher median values for lactate dehydrogenase (16.69), NAD-GDH (39.48), NADP-GDH (7.48), NADP-MDH (9.06) and lower values of NAD-ICDH (65.41). Women with stage III of PVV had lower median values for succinate dehydrogenase (9.27), NAD-MDH (26.19), and higher values for glucose-6-phosphate dehydrogenase (8.62), lactate dehydrogenase (24.67), NAD-GDH (63.81), NADP-MDH (21.05) compared to the control group. Studying the activity of NAD(P)-dependent dehydrogenases in lymphocytes at the local level during PVV allows us to evaluate the intensity and dynamics of local varicose veins progression, as well as to optimize its correction.

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 Source
http://dx.doi.org/10.1007/s10517-024-06278-7DOI Listing

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