AI Article Synopsis
- - Polycomb repressive complex 1 (PRC1) plays a key role in controlling genes that define and maintain cell identity.
- - Recent research by Szczurek et al. highlights a specific type of PRC1, called noncanonical PRC1 (ncPRC1), which adds a chemical mark (H2AK119ub1) that helps keep genes turned off.
- - ncPRC1 effectively prevents the start of transcription, ensuring that these lineage-specific genes remain inactive, thus maintaining cellular identity.
Article Abstract
Polycomb repressive complex 1 (PRC1) is an essential repressor of lineage-specific genes central to the establishment and preservation of cellular identity. Recent findings by Szczurek et al. show that the noncanonical form of PRC1 (ncPRC1), which mediates H2AK119ub1, promotes a deep OFF state at promoters by blocking transcription initiation.
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| http://dx.doi.org/10.1016/j.tig.2024.10.013 | DOI Listing |
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Article Synopsis
- - Polycomb repressive complex 1 (PRC1) plays a key role in controlling genes that define and maintain cell identity.
- - Recent research by Szczurek et al. highlights a specific type of PRC1, called noncanonical PRC1 (ncPRC1), which adds a chemical mark (H2AK119ub1) that helps keep genes turned off.
- - ncPRC1 effectively prevents the start of transcription, ensuring that these lineage-specific genes remain inactive, thus maintaining cellular identity.
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