An injectable epoxidized soybean oil/gelatin-based photothermal biogel with remarkable rapid hemostasis capability for wound repair.

The development of wound dressings with rapid hemostasis, antibacterial activity without the addition of antibiotics and on-demand removability that effectively avoid secondary damage to the wound during replacement still faces significant challenges. Herein, injectable epoxidized soybean oil/gelatin-based photothermal biogel with outstanding tissue adhesion, on-demand removability, shape-adaptability, and antibacterial performance is prepared as a removable wound dressing for wound repair. The biogel is composed of two types of hydrophilic/hydrophobic three-dimensional network structures, which interweave together through dynamic imine bonds, coordination bonds and numerous hydrogen bonds to synergistically improve injectability, self-healing, tissue adhesion, and compressive performance of the biogel. Moreover, the prepared EG-02 biogel not only has excellent thermal stability, biodegradability, hemocompatibility, and RBCs and platelet adhesion properties, but also displays outstanding cytocompatibility and the ability to promote cell migration. Furthermore, the EG-02 biogel treated with a near-infrared (NIR) laser (808 nm, 0.2 W·cm) exhibits prominent photothermal cycling stability and antibacterial performance. Notably, the EG-02 biogel presents remarkable rapid hemostasis capability, with the hemostatic time greatly shortened to 40 s and the blood loss significantly reduced to 89.2 mg. Therefore, the injectable photothermal biogel, as a fascinating candidate for on-demand removable wound dressing, has shown promising application prospects in wound repair.