AI Article Synopsis
- There is evidence suggesting that the HPA axis may not function properly in people with chronic tinnitus, but previous studies have shown mixed results, possibly due to varied clinical factors.
- This study compares salivary cortisol levels in tinnitus sufferers and healthy controls to investigate the effects of childhood trauma and anxiety on HPA-axis functioning.
- The results indicate that individuals with tinnitus who experienced childhood trauma have lower cortisol awakening responses, suggesting trauma impacts HPA function, while anxiety did not significantly affect any outcomes.
Article Abstract
Introduction: There is some evidence for hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic tinnitus, but findings are contradicting possibly due to clinical heterogeneity. This study aimed to assess differential effects of childhood trauma and anxiety on HPA-axis functioning in adults suffering from chronic subjective tinnitus with distress.
Methods: Salivary cortisol data were collected in 22 chronic subjective tinnitus sufferers (without major depression) and 29 healthy controls after awakening, at baseline, and after a low-dose (0.5 mg) dexamethasone challenge. A factorial ANCOVA was conducted to compare the main effects of group (tinnitus versus. controls), trauma, and their interaction effect on the cortisol awakening response (CAR). Linear mixed models were fitted for baseline and post-dexamethasone cortisol levels with group, sampling time, trauma, and their interactions as fixed factors and subject as the random effect. The Beck Anxiety Index, Anxiety Sensitivity Index, and Panic Disorder Severity Scale were included to investigate effects of anxiety.
Results: A significant interaction between group and trauma (F [1, 47] = 6.9755, p = 0.0112) was found, with the tinnitus group showing lower CARs (M = 5.1808, SD = 0.5821) than the comparison group (M = 5.9974, SD = 0.5251) in traumatized individuals only. No effects were found for baseline or post-dexamethasone cortisol. Anxiety scores had no effects on any of the outcome variables.
Conclusion: A differential effect of childhood trauma, but not anxiety, on the HPA-axis function in chronic subjective tinnitus was partly confirmed by the finding of a blunted CAR in tinnitus sufferers reporting early-life adversity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000542066 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.
Brain Behav
January 2025
Department of General Practice, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, China.
Introduction: Persistent postural-perceptual dizziness (PPPD) is the most prevalent chronic functional dizziness in the clinic. Unsteadiness, dizziness, or non-spinning vertigo are the main symptoms of PPPD, and they are typically aggravated by upright posture, active or passive movement, and visual stimulation. The pathogenesis of PPPD remains incompletely understood, and it cannot be attributed to any specific anatomical defect within the vestibular system.
View Article and Find Full Text PDFProfessional-patient discrepancies in assessing lung cancer radiotherapy symptoms: An international multicentre study.
Lung Cancer
December 2024
Grupo Genética en Cáncer y Enfermedades Raras, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain; Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. Electronic address:
Background And Purpose: We investigate discrepancies in the assessment of treatment-related symptoms in lung cancer between healthcare professionals and patients, and factors contributing to these discrepancies.
Materials And Methods: Data from 515 participants in the REQUITE study were analysed. Five symptoms (cough, dyspnoea, bronchopulmonary haemorrhage, chest wall pain, dysphagia) were evaluated both before and after radiotherapy.
Long-Term Outcomes of Acute Temporal Bone Fractures.
Laryngoscope
December 2024
Division of Otolaryngology - Head & Neck Surgery, Cooper University Health Care, Camden, New Jersey, U.S.A.
Objective(s): To compare the incidence of acute and chronic complications of temporal bone fractures, and identify predictors for post-injury, audiometrically confirmed hearing loss.
Methods: Retrospective cohort analysis of patients with acute temporal bone fractures who underwent both in-hospital and outpatient follow-up Otolaryngology evaluation at an academic, tertiary-care institution from January 2002 to January 2023. Otologic outcomes were compared between initial and follow-up evaluations.
Youth With Functional Abdominal Pain Disorders Have More Sleep Disturbances. A School-Based Study.
Neurogastroenterol Motil
December 2024
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Miami School of Medicine, Miami, Florida, USA.
Background: There is a bidirectional relationship between sleep and pain disturbances. Sleep disturbances increase the risk for chronic pain, while chronic pain can interfere with sleep. Hence, we assessed the subjective sleep characteristics of youth with functional abdominal pain disorders (FAPDs) compared to healthy youth and examined associations with gastrointestinal symptoms.
View Article and Find Full Text PDFEffects of a flexibly delivered group-based acceptance and commitment therapy on reducing stress and enhancing psychological wellbeing in parents of school-age children during the COVID-19 pandemic: a quasi-experimental study.
Front Public Health
December 2024
School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Introduction: COVID-19 has increased parental stress and significantly impacted the psychological well-being of individuals, especially parents of school-age children. Acceptance and Commitment Therapy posits that individuals can accept their unchangeable inner experiences (thoughts and feelings) while acting in ways aligned with their personal values, demonstrating effectiveness in reducing stress and improving psychological well-being, especially among parents of children with chronic illness. This study aimed to test the effectiveness of a group-based ACT, delivered flexibly, in improving stress and psychological well-being in parents with school-age children, regardless of their children's chronic conditions, within a real-world context.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!