Slc-ing cone synapses: Na⁺/bicarbonate co-transport regulates synaptic gain.

Neuron

Department of Biology, University of Victoria, Victoria, BC, Canada. Electronic address:

Published: November 2024

Horizontal cells provide feedback inhibition to cone axon terminals via an unidentified synaptic mechanism. In this issue of Neuron, Morikawa and colleagues demonstrate that the electrogenic bicarbonate transporter (Slc4a5), which regulates pH, plays a crucial role at this feedback synapse.

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http://dx.doi.org/10.1016/j.neuron.2024.10.021DOI Listing

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