Danneskiold-Samsøe and coworkers have developed an in silico screening pipeline based on AlphaFold2 for identifying single-pass transmembrane receptors for secreted peptides that play important roles in cell-cell signaling. Their approach can be used to deorphanize a diverse range of ligands. The overall strategy can be valuable in screening for weak and transient interactions.
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| http://dx.doi.org/10.1016/j.cels.2024.10.010 | DOI Listing |
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