AI Article Synopsis
- Ion transport is vital for cell health as it helps maintain balance in ion levels within cells.
- Synthetic molecules that imitate natural ion channels could be developed as potential cancer treatments by disrupting processes like cell death and autophagy through changes in pH and stress.
- This review highlights recent advancements in synthetic ion transport systems, particularly their types and applications in cancer therapy.
Article Abstract
Ion transport across cell membranes is crucial in maintaining ion homeostasis in cells. Synthetic molecules that can mimic the functions of natural ion channel proteins would possess great potential as therapeutic agents by promoting apoptosis or interfering with autophagic processes through perturbing the intracellular pH or inducing oxidative and osmotic stresses. However, little is known about the underlying mechanisms in terms of direct correlation between ion transport and biological functions. This review summarizes recent progress in the area of synthetic transmembrane ion transport systems, focusing on the channel type, with an emphasis on their bioapplications as anticancer agents.
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| http://dx.doi.org/10.1016/j.cbpa.2024.102544 | DOI Listing |
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