Safety profile of abdominal magnetic resonance imaging (MRI) performed for renal disease surveillance in tuberous sclerosis complex patients with vagus nerve stimulation: Safety of MRI for TSC Patients with VNS.

Seizure

Neuroscience Institute, Le Bonheur Children's Hospital, Memphis, TN, United States; Tuberous Sclerosis Center of Excellence, Le Bonheur Children's Hospital, Memphis, TN, United States; Division of Pediatric Neurology, University of Tennessee Health Science Center, 49 North Dunlap, 3rd Floor FOB, Memphis, TN 38105, United States. Electronic address:

Published: December 2024

Introduction: Individuals with tuberous sclerosis complex (TSC) often present with refractory epilepsy and may be undergoing treatment with vagus nerve stimulation (VNS) to control seizures. Surveillance magnetic resonance imaging (MRI) is necessary to monitor for the renal angiomyolipomas associated with TSC; however, MRI of the abdomen is not approved for patients withVNS therapy. We have many TSC patients with refractory epilelpsy who benefitted from VNS therapy, so we developed an MRI protocol that allows MRI of the abdomen to be performed in these patients to permit safe imaging of their kidneys. Here we report our results using this protocol.

Methods: We performed a retrospective review for all TSC patients seen from 01/01/1997 to 10/01/2022 at a single center to determine VNS implantation status. Patients with VNS implants and abdomen imaging performed according to the protocol for kidney surveillance were included.

Results: Sixteen patients with 48 total MRIs of the abdomen were found: 34 (71 %) scans were conducted under sedation and 14 (29 %) without sedation. None of the patients reported any adverse effects (pain or discomfort). No instances of VNS dysfunction were noted when re-interrogating the device immediately after completion of the imaging studies or at later neurology follow-up appointments. All MRI scans were of good quality for interpretation.

Conclusion: Abdominal MRIs performed in typical VNS exclusion zones were not associated with adverse events or VNS dysfunction. We believe this protocol is safe and permits the best method for monitoring renal disease in TSC patients with VNS.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2024.11.005DOI Listing

Publication Analysis

Top Keywords

tsc patients
16
patients vns
12
patients
10
vns
9
magnetic resonance
8
resonance imaging
8
imaging mri
8
renal disease
8
tuberous sclerosis
8
sclerosis complex
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!