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Interlaboratory assays from the fungal PCR Initiative and the Modimucor Study Group to improve qPCR detection of Mucorales DNA in serum: one more step toward standardization.
J Clin Microbiol
December 2024
Chrono-environnement UMR6249, CNRS, University of Franche-Comté, Besançon, Bourgogne-Franche-Comté, France.
Unlabelled: The aim of this study was to identify parameters influencing DNA extraction and PCR amplification efficiencies in an attempt to standardize Mucorales qPCR. The Fungal PCR Initiative Mucorales Laboratory Working Group distributed two panels of simulated samples to 26 laboratories: Panel A (six sera spiked with Mucorales DNA and one negative control serum) and Panel B (six Mucorales DNA extracts). Panel A underwent DNA extraction in each laboratory according to the local procedure and were sent to a central laboratory for testing using three different qPCR techniques: one in-house qPCR assay and two commercial assays (MucorGenius and Fungiplex).
View Article and Find Full Text PDFThe joint memory effect: challenging the selfish stigma in Huntington's disease?
Brain Commun
December 2024
Département d'Etudes Cognitives, École normale supérieure, PSL University, 75005 Paris, France.
The prevalent belief that individuals with Huntington's disease exhibit selfish behaviour, disregarding the thoughts, feelings and actions of others, has been challenged by patient organizations and clinical experts. To further investigate this issue and study whether participants with Huntington's disease can pay attention to others, a joint memory task was carried out in patients with Huntington's disease with and without a partner. This study involved 69 participants at an early stage of Huntington's disease and 56 healthy controls from the UK, France and Germany, who participated in the international Repair-HD multicentre study (NCT03119246).
View Article and Find Full Text PDFRecent Advances in Perioperative Care of Patients using New Antihyperglycaemic Drugs and Devices Dedicated to Diabetes.
Anaesth Crit Care Pain Med
December 2024
Department of Anaesthesia and intensive care Medicine, hôpital Bicêtre, AP-HP, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. Electronic address:
Patient and physician expectations regarding disease and treatment of advanced HCC: The prospective PERCEPTION1 study.
JHEP Rep
November 2024
Liver unit, Beaujon Hospital, APHP Clichy, France.
Background & Aims: We aimed to explore patient expectations regarding their treatments and prognosis in comparison to physicians' assessments in patients with advanced hepatocellular carcinoma (HCC) receiving systemic treatments.
Methods: We prospectively enrolled 205 patients in France and Belgium with Barcelona Clinic Liver Cancer (BCLC) stage B/C HCC receiving systemic treatment (NCT04823754). Patients completed a 28-question survey and the hospital anxiety and depression scale (HADS), while physicians filled a 17-question survey after the initial consultation.
Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.
Clin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
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