Introduction: Since the COVID-19 outbreak escalated to pandemic levels, numerous hospitals deferred elective interventions. Studies reporting the incidence, presentation, severity, and outcomes in the surgical management of biliary diseases differ before, during and after the pandemic.
Objective: Evaluate the presentation of biliary pathology by diagnosis and Parkland Grading Scale in patients whose surgeries were postponed due to the pandemic, and who were later surgically intervened.
Methods: A retrospective study was conducted. Patients with biliary pathology who had a scheduled cholecystectomy canceled during the pandemic were included. Student's t-test and Chi-Square tests were employed for statistical analysis.
Results: A total of 520 patients were evaluated, cholelithiasis was the most common diagnosis in 74.4%. Grade III on the Parkland Grading Scale (PGS) was the most prevalent at 43.7%. Significant differences were observed between genders (p = 0.000) and emergency versus elective surgeries (p = 0.000) in relation to the PGS. Hospitalization duration also exhibited a statistically significant difference between emergency and elective surgeries (p = 0.000).
Conclusion: Most patients presented a Grade III on the PGS, reflecting a one-level increase compared to pre-pandemic literature prevalence. More studies are needed to evaluate the real impact of the pandemic on biliary pathology.
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http://dx.doi.org/10.5281/zenodo.13381474 | DOI Listing |
Nihon Shokakibyo Gakkai Zasshi
January 2025
Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine.
A 78-year-old male patient came to our hospital with a chief complaint of fever. Computed tomography revealed an indistinct tumor in the pancreatic head, along with dilatation of the bile duct and main pancreatic duct. An endoscopic transpapillary biopsy demonstrated adenocarcinoma in the glandular epithelium and a dense formation of quasi-round cells.
View Article and Find Full Text PDFLangenbecks Arch Surg
January 2025
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University, Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Purpose: The impact of body-cavity depth on open (OLR) and laparoscopic liver resection (LLR) of segment 7 remains unclear. Therefore, we investigated the influence of body-cavity depth at the upper-right portion of the abdomen on LLR and OLR of segment 7.
Methods: In total, 101 patients who underwent segment-7 liver resection over 2010-2023 were included.
Liver Int
February 2025
Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Background And Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive biliary inflammation and fibrosis, leading to liver cirrhosis and cholangiocarcinoma. GPBAR1 (TGR5) is a G protein-coupled receptor for secondary bile acids. In this study, we have examined the therapeutic potential of BAR501, a selective GPBAR1 agonist in a PSC model.
View Article and Find Full Text PDFEuroasian J Hepatogastroenterol
December 2024
Department of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi, India.
Background: The purpose of the present study was to evaluate clinicopathological characteristics, patterns of recurrence, survival outcomes, and implications for the addition of chemoradiotherapy for patients with resected perihilar and intrahepatic cholangiocarcinoma (CCA).
Materials And Methods: For the present retrospective study, we identified 38 and 10 patients with resected perihilar and intrahepatic CCA. In perihilar CCA, adjuvant treatment was given as chemotherapy ( = 13) or chemoradiotherapy ( = 10).
Int J Surg Pathol
January 2025
Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
IgG4-related disease (IgG4-RD) is an autoimmune disease of unknown cause. is a transcription factor involved in immune responses, and its dysfunction leads to uncontrolled immune responses. We performed, to our knowledge, the first methylation analysis in type 1 autoimmune pancreatitis (denoted simply as AIP), a representative IgG4-RD.
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