AI Article Synopsis
- Olorofim was tested against various species and showed strong effectiveness, with a minimum inhibitory concentration (MIC) range between 0.008 and 0.06 µg/mL.
- Olorofim maintained its potent activity even against strains that had high fluconazole resistance (MICs of 16 µg/mL or more).
- The overall geometric mean MIC for olorofim across all isolates was very low, at 0.010 µg/mL, indicating its potential as a valuable treatment option.
Article Abstract
We evaluated the activity of olorofim against species. Olorofim demonstrated potent activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).
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| http://dx.doi.org/10.1128/aac.00988-24 | DOI Listing |
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