Advanced analytical methods for multi-spectral transmission imaging optimization: enhancing breast tissue heterogeneity detection and tumor screening with hybrid image processing and deep learning.

Light sources exhibit significant absorption and scattering effects during the transmission through biological tissues, posing challenges in identifying heterogeneities in multi-spectral images. This paper introduces a fusion of techniques encompassing the spatial pyramid matching model (SPM), modulation and demodulation (M_D), and frame accumulation (FA). These techniques not only elevate image quality but also augment the precision of heterogeneous classification in multi-spectral transmission images (MTI) within deep learning network models (DLNM). Initially, experiments are designed to capture MTI of phantoms. Subsequently, the images are preprocessed separately through a combination of different techniques such as SPM, M_D and FA. Ultimately, multi-spectral fusion pseudo-color images derived from U-Net semantic segmentation are fed into VGG16/19 and ResNet50/101 networks for heterogeneous classification. Among them, different combinations of SPM, M_D and FA significantly enhance the quality of images, facilitating the extraction of heterogeneous feature information from multi-spectral images. In comparison to the classification accuracy achieved in the original image VGG and ResNet network models, all images after preprocessing effectively improved the classification accuracy of heterogeneities. Following scatter correction, images processed with 3.5 Hz modulation-demodulation combined with frame accumulation (M_D-FA) attain the highest classification accuracy for heterogeneities in the VGG19 and ResNet101 models, achieving accuracies of 95.47% and 98.47%, respectively. In conclusion, this paper utilizes different combinations of SPM, M_D and FA techniques to not only enhance the quality of images but also further improve the accuracy of DLNM in heterogeneous classification, which will promote the clinical application of MTI technique in breast tumor screening.