Cardiovascular disease (CVD) is one of the most prevalent health threats globally. Traditional diagnostic methods for CVDs, including electrocardiography, ultrasound, and cardiac magnetic resonance imaging, have inherent limitations in real-time monitoring and high-resolution visualization of cardiovascular pathophysiology. In recent years, optical imaging technology has gained considerable attention as a non-invasive, high-resolution, real-time monitoring solution in the study and diagnosis of CVD. This review discusses the latest advancements, and applications of optical techniques in cardiac imaging. We compare the advantages of optical imaging over traditional modalities and especially scrutinize techniques such as optical coherence tomography, photoacoustic imaging, and fluorescence imaging. We summarize their investigations in atherosclerosis, myocardial infarction, and heart valve disease, etc. Additionally, we discuss challenges like deep-tissue imaging and high spatiotemporal resolution adjustment, and review existing solutions such as multimodal integration, artificial intelligence, and enhanced optical probes. This article aims to drive further development in optical imaging technologies to provide more precise and efficient tools for early diagnosis, pathological mechanism exploration, and treatment of CVD.
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http://dx.doi.org/10.1016/j.isci.2024.111216 | DOI Listing |
Circ Cardiovasc Interv
January 2025
Division of Cardiology, Department of Medicine, University of Washington Medical Center, Seattle (E.J.S., T. Salahuddin, J.A.D.).
Background: Intravascular imaging (IVI) is widely recognized to improve outcomes after percutaneous coronary intervention (PCI). However, IVI is underutilized and is not yet established as a performance measure for quality PCI.
Methods: We examined temporal trends of IVI use for all PCIs performed at Veterans Affairs hospitals in the United States from 2010 to 2022 using retrospective observational cohorts.
Dalton Trans
January 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
-β, β-β' trifused porphyrins incorporating two distinct active methylene groups (MN = malononitrile and IND = 1,3-indanedione) and their corresponding metal complexes with Cu(II) and Zn(II) have been synthesized with good to excellent yields and characterized by various spectroscopic techniques and spectrometric methods. Single crystal X-ray analysis of the Zn(II) complex ZnTFPMB(MN) (where TFP = trifused porphyrin and MB = mono benzo) revealed a nonplanar 'armchair' type conformation with a twist angle of 24.10°.
View Article and Find Full Text PDFNeurophotonics
January 2025
Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, Missouri, United States.
Significance: Decoding naturalistic content from brain activity has important neuroscience and clinical implications. Information about visual scenes and intelligible speech has been decoded from cortical activity using functional magnetic resonance imaging (fMRI) and electrocorticography, but widespread applications are limited by the logistics of these technologies.
Aim: High-density diffuse optical tomography (HD-DOT) offers image quality approaching that of fMRI but with the silent, open scanning environment afforded by optical methods, thus opening the door to more naturalistic research and applications.
J Biomed Opt
January 2025
Tel Aviv University, Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv, Israel.
Significance: Imaging flow cytometry allows highly informative multi-point cell analysis for biological assays and medical diagnosis. Rapid processing of the imaged cells during flow allows real-time classification and sorting of the cells. Off-axis holography enables imaging flow cytometry without chemical cell staining but requires digital processing to the optical path delay profile for each frame before the cells can be classified, which slows down the overall processing throughput.
View Article and Find Full Text PDFACS Sens
January 2025
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ferroptosis is the result of the accumulation of iron-dependent lipid peroxidation. Studies have shown that ferroptosis plays an important role in the pathogenesis of NAFLD. Herein, we have developed a viscosity-sensitive fluorescence probe PTSO with near-infrared emission and a large Stokes shift, which were achieved by introducing the sulfone group into the dioxothiochromen-malononitrile fluorophore as an electron-withdrawing group.
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