The extracellular matrix molecule Collagen XVIII/CLE-1 affects neuronal dendritic spines.

The extracellular matrix (ECM) is a rich collection of macromolecules that influences numerous cellular functions; however, its roles at neuronal synapses are not fully understood. Using dendritic spines of GABAergic neurons as a model, we found that the ECM component Collagen XVIII/ CLE-1 is localized in close proximity to dendritic spines and is important for their normal development and maintenance. Specific expression of in GABAergic neurons partially rescued the reduction in spine number in mutants Together, our findings suggest that Collagen XVIII/ CLE-1 regulates dendritic spines, in part through local CLE-1 deposition from GABAergic neurons.