AI Article Synopsis
- Granulocyte/monocyte adsorption therapy can help treat mild-to-moderate inflammatory bowel disease by removing activated immune cells, and its efficacy was tested using new columns designed for better adsorption.
- In a study with rats suffering from colitis, the new columns led to improved tissue health but didn’t significantly enhance the rate of immune cell adsorption into the blood.
- The therapy was associated with an increase in newly formed B cells that produced higher levels of interleukin-10, suggesting they play a role in reducing inflammation and controlling colitis symptoms.
Article Abstract
Introduction: Granulocyte/monocyte adsorption therapy can manage mild-to-moderate inflammatory bowel disease by removing activated granulocytes and monocytes. We evaluated granulocyte/monocyte adsorption using new columns with reduced bead size and theoretically enhanced adsorption.
Methods: We assessed granulocyte/monocyte adsorption in rats with colitis by analyzing cell changes and cytokine production.
Results: Granulocyte/monocyte adsorption with the new columns improved histology in rats with colitis. Contrary to expectations, the adsorption rate of granulocytes/monocytes into the blood did not show a significant improvement. However, flow cytometry showed increased B cells in peripheral blood mononuclear cells and newly formed B cells in the bone marrow, which produced more interleukin-10 than peripheral blood B cells. Newly formed B cells adoptively transferred into colitis rats accumulated at the inflammation site and tended to inhibit intestinal shortening.
Conclusions: Newly formed B cells with strong interleukin-10 production may alleviate inflammation. The new columns suggest potential for controlling colitis.
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| http://dx.doi.org/10.1111/1744-9987.14234 | DOI Listing |
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