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Effects of Lomerizine and Its Metabolite on Glioblastoma Cells.
Anticancer Res
July 2024
School of Pharmacy, Hyogo Medical University, Kobe, Japan.
Background/aim: Glioblastoma is an incurable cancer with limited treatment options and a low survival rate. Temozolomide is the standard marketed small-molecule agent for glioblastoma therapy; therefore, we aimed to find new drugs among the marketed medicines for brain diseases because of their cerebral migratory property and found lomerizine, used for the treatment of migraine.
Materials And Methods: We evaluated the effect of lomerizine and its metabolites against U251 glioblastoma cells and temozolomide-resistant cells, T98G and GB-1, caused by the expression of O(6)-methylguanine-DNA methyltransferase or P-glycoprotein, compared with temozolomide, and combined with it.
Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses.
J Ethnopharmacol
October 2024
The Second Affiliation Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230061, China. Electronic address:
Ethnopharmacological Relevance: Anshen Dingzhi prescription (ADP), documented in "Yi Xue Xin Wu", is a famous prescription for treating panic-related mental disorders such as post-traumatic stress disorder (PTSD). However, the underlying mechanism remains unclear.
Aim Of The Study: This study aimed to investigate the mechanisms by which ADP intervened in PTSD-like behaviors.
Antibody Conjugated Nano-Enabled Drug Delivery Systems Against Brain Tumors.
J Pharm Sci
June 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University 06100, Ankara, Turkey.
The use of antibody-conjugated nanoparticles for brain tumor treatment has gained significant attention in recent years. Nanoparticles functionalized with anti-transferrin receptor antibodies have shown promising results in facilitating nanoparticle uptake by endothelial cells of brain capillaries and post-capillary venules. This approach offers a potential alternative to the direct conjugation of biologics to antibodies.
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