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Respiratory Outcomes and Aspergillus Serology Following Elexacaftor/Tezacaftor/Ivacaftor Therapy in People with Cystic Fibrosis and a History of Aspergillus fumigatus Infection.
Lung
January 2025
Mother and Child Department, Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Purpose: The study evaluated the effects of elexacaftor/tezacaftor/ivacaftor (ETI) therapy in people with cystic fibrosis (pwCF) and a clinical history of Aspergillus fumigatus (AF) infection.
Methods: This prospective cohort study included pwCF who initiated ETI therapy and had received antifungal treatment in the preceding five years due to allergic bronchopulmonary aspergillosis (ABPA group) or other AF-related clinical manifestations (AF group). A control group of pwCF with no prior respiratory cultures positive for AF was also included.
Factors governing formation from methyl halogens and pseudohalogens.
Nat Commun
January 2025
Department of Chemistry, Michigan State University, East Lansing, Michigan, USA.
The formation of following the double ionization of small organic compounds via a roaming mechanism, which involves the generation of H and subsequent proton abstraction, has recently garnered significant attention. Nonetheless, a cohesive model explaining trends in the yield of characterizing these unimolecular reactions is yet to be established. We report yield and femtosecond time-resolved measurements following the strong-field double ionization of CHX molecules, where X = OD, Cl, NCS, CN, SCN, and I.
View Article and Find Full Text PDFOperator means, barycenters, and fixed point equations.
Acta Sci Math
July 2024
HUN-REN Alfréd Rényi Institute of Mathematics, Reáltanoda U. 13-15, Budapest, H-1053 Hungary.
The seminal work of Kubo and Ando (Math Ann 246:205-224, 1979/80) provided us with an axiomatic approach to means of positive operators. As most of their axioms are algebraic in nature, this approach has a clear algebraic flavour. On the other hand, it is highly natural to take the geomeric viewpoint and consider a distance (understood in a broad sense) on the cone of positive operators, and define the mean of positive operators by an appropriate notion of the center of mass.
View Article and Find Full Text PDFDrillers and bulldozer operators have experienced exceptionally high exposures to respirable crystalline silica in US surface coal mines.
Occup Environ Med
December 2024
School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Introduction: Previous studies suggest respirable crystalline silica (RCS) is an important driver of resurgent pneumoconiosis among US coal miners. Although greater attention has been focused on dust exposures in underground coal miners, surface miners are also at risk of severe disease. This study explores RCS exposure in this population.
View Article and Find Full Text PDFInfluence of Particle Rotation on the Shear Characteristics of Calcareous-Sand and Silica-Bead Granular Materials.
Materials (Basel)
November 2024
Higher Technical School of Civil Engineers, Technical University of Madrid, 28039 Madrid, Spain.
The shear strength and resistance of granular materials are critical indicators in geotechnical engineering and infrastructure construction. Both sliding and rotation influence the energy evolution of soil granular motion during shear. To examine the effects of particle rotation on shear damage and energy evolution in granular systems, we first describe the transformation of irregularly shaped particles into regular shapes via geometrical parameters, ensuring the invariance of energy density and density.
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