AI Article Synopsis
- Apoptosis is a crucial process of programmed cell death that occurs in all multicellular organisms.
- Recent research using a method called CETSA has discovered a new regulatory mechanism for apoptosis involving the cleavage of nuclear substrates.
- This discovery indicates there may be an important amplification step in the apoptosis process that takes place inside the nucleus.
Article Abstract
Apoptosis, a well-established program of cell death, is fundamental to all multicellular organisms. Recent studies of apoptosis initiation events using proteome-wide cellular thermal shift assay (CETSA) have revealed a novel regulatory mechanism involving the cleavage of nuclear substrates. This finding suggests a previously unrecognized amplification step in apoptosis occurring within the nucleus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tcb.2024.11.001 | DOI Listing |
Publication Analysis
Top Keywords
step apoptosis
8
proteome-wide cetsa
4
cetsa reveals
4
reveals step
4
apoptosis
4
apoptosis control
4
control apoptosis
4
apoptosis well-established
4
well-established program
4
program cell
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!